The σ70-like motif:: A eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis
The σ70-like motif:: A eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis
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DOI：
10.1016/s1097-2765(02)00438-0
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发表时间：
2002-02-01
期刊：
影响因子：
16
通讯作者：
Baserga, SJ
中科院分区：
文献类型：
--
作者：
Wehner, KA;Baserga, SJ
人们对核仁 RNA 结合蛋白在核糖体生物发生中的作用知之甚少，尽管基于前 rRNA 的严格折叠要求显然需要它们。我们已经鉴定了一个 RNA 结合蛋白超家族，其成员是核糖体生物发生的不同阶段所必需的。 Imp4 超家族由五个单独的家族（Imp4、Rpf1、Rpf2、Brx1 和 Ssf）组成，它们都具有 sigma(70) 样基序，这是一种具有原核起源的真核 RNA 结合结构域。 Imp4 超家族成员与 RNA 相关联，这些 RNA 与其在核糖体生物发生中的独特作用一致，并表明它们发挥作用的机制。
Little is understood about the role of nucleolar RNA binding proteins in ribosome biogenesis, although there is a clear need for them based on the strict folding requirements of the pre-rRNA. We have identified a superfamily of RNA binding proteins whose members are required for different stages of ribosome biogenesis. The Imp4 superfamily is composed of five individual families (Imp4, Rpf1, Rpf2, Brx1, and Ssf) that all possess the sigma(70)-like motif, a eukaryotic RNA binding domain with prokaryotic origins. The Imp4 superfamily members associate with RNAs that are consistent with their distinct roles in ribosome biogenesis and suggest the mechanisms by which they function.