Standardized Uptake Value in High Uptake Area on Positron Emission Tomography with 18F-FRP170 as a Hypoxic Cell Tracer Correlates with Intratumoral Oxygen Pressure in Glioblastoma
Standardized Uptake Value in High Uptake Area on Positron Emission Tomography with 18F-FRP170 as a Hypoxic Cell Tracer Correlates with Intratumoral Oxygen Pressure in Glioblastoma
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DOI：
10.1007/s11307-013-0670-7
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发表时间：
2014-02-01
影响因子：
3.1
通讯作者：
Takai, Yoshihiro
中科院分区：
文献类型：
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作者：
Beppu, Takaaki;Terasaki, Kazunori;Takai, Yoshihiro
本研究的目的是阐明使用一种新的乏氧细胞示踪剂1-（2-[F-18]fluoro-1-[hydroxymethyl]ethoxy）methyl-2-nitroimidazole（F-18-FRP 170）进行正电子发射断层扫描（PET）的可靠性。在肿瘤内显示F-18-FRP 170高（高摄取区域）和相对低（低摄取区域）蓄积的区域计算平均标准化摄取值（SUV）和标准化SUV。在这些区域，在肿瘤切除过程中使用微电极测量肿瘤内氧分压（tpO（2）），高摄取区的平均tpO（2）显著低于低摄取区。在高摄取区，标准化SUV和tpO（2）之间存在明显的负相关性。目前的研究结果表明，F-18-FRP 170 PET上的高蓄积代表胶质母细胞瘤中有活力的缺氧组织。
The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[F-18]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole (F-18-FRP170).Twelve patients with glioblastoma underwent F-18-FRP170 PET before tumor resection. Mean standardized uptake value (SUV) and normalized SUV were calculated at regions within a tumor showing high (high-uptake area) and relatively low (low-uptake area) accumulations of F-18-FRP170. In these areas, intratumoral oxygen pressure (tpO(2)) was measured using microelectrodes during tumor resection.Mean tpO(2) was significantly lower in the high-uptake area than in the low-uptake area. A significant negative correlation was evident between normalized SUV and tpO(2) in the high-uptake area.The present findings suggest that high accumulation on F-18-FRP170 PET represents viable hypoxic tissues in glioblastoma.