Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
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DOI：
10.1038/bjc.1977.186
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发表时间：
1977-08
影响因子：
8.8
通讯作者：
Faber, M
中科院分区：
文献类型：
--
作者：
Himelstein-Braw, R;Peters, H;Faber, M
在12个尸检标本中研究了患有腹部肿瘤的儿童的卵巢。来自25名死于事故或短期急性疾病的儿童的卵巢作为对照。所有正常儿童的卵巢都显示卵泡生长，但67%的腹部肿瘤儿童的卵泡发育受到抑制。研究了细胞毒性药物和/或腹部照射对卵巢形态学的影响。正常的卵巢只在没有接受化疗或接受短期化疗的儿童中发现。所有单独接受放射治疗或与化疗联合治疗的患者都有严重的卵巢损伤：所有病例中卵泡生长均受到抑制，大多数病例中小的非生长卵泡数量明显减少。有人认为，腹部照射可能会损害卵泡发育以及破坏小卵泡。
The ovaries of children with abdominal tumours were studied in 12 autopsy specimens. Ovaries from 25 children who died in accidents or after a short acute disease served as controls. All ovaries from normal children showed follicle growth, but follicle development was inhibited in 67% of the children with abdominal tumours. The effect of treatment with cytotoxic drugs and/or abdominal irradiation on ovarian morphology was investigated. Normal ovaries were found only in children who had received no chemotherapy or a short course. All patients who had been treated with radiation therapy either alone or in conjunction with chemotherapy had severely damaged ovaries: follicle growth was inhibited in all cases, and the number of small non-growing follicles was markedly reduced in most. It is argued that abdominal irradiation might impair follicle development as well as destroy small follicles.