Associations among Mammographic Density, Circulating Sex Hormones, and Polymorphisms in Sex Hormone Metabolism Genes in Postmenopausal Women
Associations among Mammographic Density, Circulating Sex Hormones, and Polymorphisms in Sex Hormone Metabolism Genes in Postmenopausal Women
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绝经后女性乳房X线密度、循环性激素和性激素代谢基因多态性之间的关联
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
D. Easton
中科院分区：
文献类型：
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作者：
R. Warren;J. Skinner;E. Sala;E. Denton;M. Dowsett;E. Folkerd;C. Healey;A. Dunning;D. Doody;B. Ponder;R. Luben;N. Day;D. Easton
乳房x线摄影密度和血清性激素水平是乳腺癌的重要危险因素，但它们之间的关系尚不清楚。我们研究了这些表型，以及与性激素代谢相关基因的单核苷酸多态性（SNP），在一项来自诺福克欧洲癌症和营养前瞻性调查的1413名绝经后妇女的横断面研究中。所有女性均为绝经后10年，在抽样前3个月未接受激素替代治疗。研究了7种性激素（雌二醇、睾酮、性激素结合球蛋白（SHBG）、雄烯二酮、17- oh孕酮、雌酮、硫酸雌酮）的血清水平和CYP17、CYP19、EDH17B2、SHBG、COMT、CYP1B1基因的15个snp。通过国家乳房筛查项目确定最接近血样的乳房x线照片，并由三名放射科医生使用博伊德六类和沃尔夫四类量表进行视觉评估。我们发现乳腺x线摄影密度与SHBG水平呈弱正相关（P = 0.09），但与其他激素无相关性。没有一个snp，包括那些先前显示与雌二醇或SHBG相关的snp，显示出与密度的显著关联。我们得出结论，乳房x线摄影密度在很大程度上与绝经后类固醇激素水平无关，这表明这些危险因素在很大程度上具有独立的病因，并表明它们可能是乳腺癌风险的独立预测因素。（癌症流行病学与生物标志物，2006;15(8):1502-08）
Mammographic density and serum sex hormone levels are important risk factors for breast cancer, but their associations with one another are unclear. We studied these phenotypes, together with single nucleotide polymorphisms (SNP) in genes related to sex hormone metabolism, in a cross-sectional study of 1,413 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition-Norfolk. All women were >1 year postmenopausal and had not taken hormone replacement therapy for >3 months before sampling. Serum levels of 7 sex hormones [estradiol, testosterone, sex hormone-binding globulin (SHBG), androstenedione, 17-OH-progesterone, estrone, and estrone sulfate] and 15 SNPs in the CYP17, CYP19, EDH17B2, SHBG, COMT, and CYP1B1 genes were studied. Mammograms nearest in time to the blood sampling were identified through the national breast screening program and visually assessed by three radiologists using the Boyd six-category and Wolfe four-category scales. We found a weak positive association between mammographic density and SHBG levels (P = 0.09) but no association with any other hormones. None of the SNPs, including those shown previously to be associated with estradiol or SHBG, showed significant associations with density. We conclude that mammographic density is largely independent of postmenopausal steroid hormone levels, indicating that these risk factors have, to a large extent, an independent etiology and suggesting that they may be independent predictors of breast cancer risk. (Cancer Epidemiol Biomarkers Prev 2006;15(8):1502-08)
DOI：
10.1093/jnci/95.1.30
发表时间：
2003-01-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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作者：
Greendale, GA;Reboussin, BA;Ursin, G
通讯作者：
Ursin, G