The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety.
The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety.
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DOI：
10.1523/jneurosci.2335-09.2009
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发表时间：
2009-09-16
期刊：
影响因子：
--
通讯作者：
Whalen PJ
中科院分区：
文献类型：
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作者：
Kim MJ;Whalen PJ
在这里，我们使用扩散张量成像（DTI），并表明杏仁核和前额叶皮质之间的轴突通路的强度预测特质焦虑的个体差异。一个功能性磁共振成像（fMRI）功能定位器，已被证明产生可靠的杏仁核激活收集在20个精神健康的受试者。体素回归分析使用这种功能磁共振杏仁核反应作为回归因子进行分数各向异性（FA）图像来自DTI。这项分析确定了杏仁核和腹内侧前额叶皮质之间的白色物质通路。这种假定的杏仁核-前额叶通路的结构完整性的个体差异与特质焦虑水平呈负相关（即，较高的路径强度预测较低的焦虑）。更一般地说，这项研究说明了一个策略，结合功能磁共振成像和DTI，以确定预测行为结果的结构途径的个体差异。
Here we used diffusion tensor imaging (DTI) and showed that the strength of an axonal pathway identified between the amygdala and prefrontal cortex predicted individual differences in trait anxiety. A functional magnetic resonance imaging (fMRI) functional localizer that has been shown to produce reliable amygdala activation was collected in twenty psychiatrically healthy subjects. Voxelwise regression analyses using this fMRI amygdala reactivity as a regressor were performed on fractional anisotropy (FA) images derived from DTI. This analysis identified a white matter pathway between the amygdala and ventromedial prefrontal cortex. Individual differences in the structural integrity of this putative amygdala-prefrontal pathway were inversely correlated with trait anxiety levels (i.e., higher pathway strength predicted lower anxiety). More generally, this study illustrates a strategy for combining fMRI and DTI to identify individual differences in structural pathways that predict behavioral outcomes.