Umbilical serum insulin-like growth factor 1 (IGF-1) in newborns:: Effects of gestational age, postnatal age, and nutrition
Umbilical serum insulin-like growth factor 1 (IGF-1) in newborns:: Effects of gestational age, postnatal age, and nutrition
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DOI：
10.1024/0300-9831.73.5.343
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发表时间：
2003-10-01
影响因子：
2.3
通讯作者：
Yönem, Ö
中科院分区：
文献类型：
--
作者：
Büyükkayhan, D;Tanzer, F;Yönem, Ö
目的：本研究的目的是确定营养、胎龄和出生体重与新生儿血清胰岛素样生长因子I（IGF-1）水平之间的关系。方法：第一研究组由60名新生儿组成，其中30名用母乳喂养，其余用婴儿配方奶粉喂养。从所有新生儿中获得了出生后第1天和第7天的血清样本。72例孕妇及其新生儿脐带血血清样本在分娩病房的研究组。结果：母乳喂养的新生儿血清IGF-1浓度显著高于对照组（p < 0.05），脐血IGF-1水平与出生体重呈负相关（p <0.05），与胎龄呈正相关（p < 0.05）。结论：新生儿期IGF-1水平受胎龄、出生体重及营养状况的影响。
Aim: The aim of this study was to determine the relationship,between nutrition, gestational age, and birth weight, and serum insulin-like growth factor I (IGF-1) levels in newborns,Method: The first study group consisted of sixty newborns; thirty were fed with human breast milk and the others were fed with infant formula. Serum samples were obtained from all, the newborns on days one and seven of life. Seventy-two pregnant women and their neonatal cord blood serum samples were obtained in a labor ward in the study group. All the serum samples were analyzed for IGF-1 by immunoassay.Result: Newborns fed with human milk had higher serum IGF-1 concentrations compared to formula-fed controls, (p < 0.05).,Cord IGF-1 levels showed a negative correlation with birthweight (p < 0.05) and a positive correlation with gestational age (p < 0.05).Conclusion: These findings suggest that IGF-1 levels during the neonatal period are influenced by gestational age, birth weight, and nutrition.