Considering how biological sex impacts immune responses and COVID-19 outcomes
Considering how biological sex impacts immune responses and COVID-19 outcomes
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DOI：
10.1038/s41577-020-0348-8
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发表时间：
2020-06-11
影响因子：
100.3
通讯作者：
Klein, Sabra L.
中科院分区：
文献类型：
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作者：
Scully, Eileen P.;Haverfield, Jenna;Klein, Sabra L.
为什么男性比女性更容易感染严重的COVID-19？在这一观点中，Sabra Klein及其同事认为免疫系统中的性别差异可能导致这种性别偏见。在COVID-19大流行中出现了死亡率的男性偏见，这与其他病毒感染的发病机制一致。生物学上的性别差异可能表现在对感染的易感性、早期发病机制、先天性病毒控制、适应性免疫反应或在感染消退中炎症和组织修复的平衡。我们讨论了COVID-19大流行的现有性别分类流行病学数据，介绍了免疫的性别差异特征，并强调了COVID-19严重程度的潜在性别差异。我们认为，免疫发病机制的性别差异将为COVID-19的机制提供信息，确定治疗干预的要点，并改进疫苗设计和提高疫苗效力。
Why are males more susceptible to severe COVID-19 than females? In this Perspective, Sabra Klein and colleagues consider the sex differences in the immune system that may contribute to this sex bias.A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with the pathogenesis of other viral infections. Biological sex differences may manifest themselves in susceptibility to infection, early pathogenesis, innate viral control, adaptive immune responses or the balance of inflammation and tissue repair in the resolution of infection. We discuss available sex-disaggregated epidemiological data from the COVID-19 pandemic, introduce sex-differential features of immunity and highlight potential sex differences underlying COVID-19 severity. We propose that sex differences in immunopathogenesis will inform mechanisms of COVID-19, identify points for therapeutic intervention and improve vaccine design and increase vaccine efficacy.