Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome
Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome
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DOI：
10.1136/gut.42.6.845
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发表时间：
1998-06-01
期刊：
影响因子：
24.5
通讯作者：
Hongo, M
中科院分区：
文献类型：
--
作者：
Fukudo, S;Nomura, T;Hongo, M
背景-促肾上腺皮质激素释放激素（CRH）在调节应激动物的肠动力中起关键作用。目的-评价CRH对人类肠动力的作用，并确定肠易激综合征（IBS）患者是否对CRH有过度反应。受试者-10例根据罗马标准诊断的IBS患者和10例健康对照。方法-CRH结果：CRH能诱导两组大鼠降结肠运动（P
Background-Corticotropin-releasing hormone (CRH) plays a key role in modulating intestinal motility in stressed animals.Aims-To evaluate the effect of CRH on intestinal motility in humans and to determine whether patients with irritable bowel syndrome (IBS) have an exaggerated response to CRH.Subjects-Ten IBS patients diagnosed by Rome criteria and 10 healthy controls.Methods-CRH (2 mu g/kg) was intravenously administered during duodenal and colonic manometry and plasma adrenocorticotropic hormone (ACTH) was measured by radioimmunoassay.Results-CRH induced motility of the descending colon in both groups (p