Current concepts in clinical radiation oncology.
Current concepts in clinical radiation oncology.
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DOI：
10.1007/s00411-013-0497-2
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发表时间：
2014-03
影响因子：
1.7
通讯作者：
Belka C
中科院分区：
文献类型：
--
作者：
Orth M;Lauber K;Niyazi M;Friedl AA;Li M;Maihöfer C;Schüttrumpf L;Ernst A;Niemöller OM;Belka C
基于其强大的诱导肿瘤细胞死亡和消除克隆生存的能力，放射治疗是多种癌症治疗方法的关键部分。许多临床试验证明，改善局部控制与提高总体存活率之间存在明显的相关性。然而，尽管取得了所有进展，但基于辐射的治疗方法的有效性仍然受到不同技术、生物和临床限制。原则上，可以区分以下主要问题：(1)几个肿瘤的固有辐射抵抗力高于周围正常组织，(2)肿瘤或危险区域的真实病理解剖边界不能完全识别，(3)在给定的治疗系列中不能适当调整治疗量，(4)肿瘤和正常组织对辐射的反应的个体异质性是巨大的。目前，放射肿瘤学的研究工作主要沿着三个方向进行，以解决这些局限性：(1)分子靶向制剂和基于组学的筛查和分层程序的实施；(2)治疗计划、成像和剂量应用的准确性的改进；以及(3)其他类型辐射的临床实施，包括质子和重离子。这些策略中的几个已经显示出在临床结果方面有希望的改善。然而，许多悬而未决的问题仍然存在，个体化治疗方法是一个关键问题。本文对肿瘤放射治疗的现状进行了总结和讨论，重点介绍了近期影响放射肿瘤学领域的新方面和新进展。
Based on its potent capacity to induce tumor cell death and to abrogate clonogenic survival, radiotherapy is a key part of multimodal cancer treatment approaches. Numerous clinical trials have documented the clear correlation between improved local control and increased overall survival. However, despite all progress, the efficacy of radiation-based treatment approaches is still limited by different technological, biological, and clinical constraints. In principle, the following major issues can be distinguished: (1) The intrinsic radiation resistance of several tumors is higher than that of the surrounding normal tissue, (2) the true patho-anatomical borders of tumors or areas at risk are not perfectly identifiable, (3) the treatment volume cannot be adjusted properly during a given treatment series, and (4) the individual heterogeneity in terms of tumor and normal tissue responses toward irradiation is immense. At present, research efforts in radiation oncology follow three major tracks, in order to address these limitations: (1) implementation of molecularly targeted agents and ‘omics’-based screening and stratification procedures, (2) improvement of treatment planning, imaging, and accuracy of dose application, and (3) clinical implementation of other types of radiation, including protons and heavy ions. Several of these strategies have already revealed promising improvements with regard to clinical outcome. Nevertheless, many open questions remain with individualization of treatment approaches being a key problem. In the present review, the current status of radiation-based cancer treatment with particular focus on novel aspects and developments that will influence the field of radiation oncology in the near future is summarized and discussed.
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DOI：
10.1186/1748-717x-8-65
发表时间：
2013-03-19
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Barazzuol L;Jena R;Burnet NG;Meira LB;Jeynes JC;Kirkby KJ;Kirkby NF
通讯作者：
Kirkby NF
影响因子：
168.9
作者：
Albain, Kathy S.;Swann, R. Suzanne;Rusch, Valerie W.;Turrisi, Andrew T., III;Shepherd, Frances A.;Smith, Colum;Chen, Yuhchyau;Livingston, Robert B.;Feins, Richard H.;Gandara, David R.;Fry, Willard A.;Darling, Gail;Johnson, David H.;Green, Mark R.;Miller, Robert C.;Ley, Joanne;Sause, Willliam T.;Cox, James D.
通讯作者：
Cox, James D.
影响因子：
11.2
作者：
Apel, Anja;Herr, Ingrid;Mayer, Andreas
通讯作者：
Mayer, Andreas
影响因子：
2.6
作者：
Andreassen, C. N.;Alsner, J.;Overgaard, J.
通讯作者：
Overgaard, J.
DOI：
10.1186/1748-717x-6-2
发表时间：
2011-01-07
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Beal K;Abrey LE;Gutin PH
通讯作者：
Gutin PH