Study of onset time-shift and injection duration in DCE-MRI: a comparison of a reference region model with the general kinetic model
Study of onset time-shift and injection duration in DCE-MRI: a comparison of a reference region model with the general kinetic model
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DOI：
10.1002/nbm.1473
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发表时间：
2010-05-01
影响因子：
2.9
通讯作者：
Liu, Ho-Ling
中科院分区：
文献类型：
--
作者：
Hsiao, Ing-Tsung;Liao, Yen-Peng;Liu, Ho-Ling
在动态对比增强磁共振成像（DCE-MRI）中，需要对动脉输入函数（AIF）进行采样，以便使用一般动力学模型（GKM）进行分析。或者，可以采用最近提出的参考区域模型（RRM）来避免获取AIF的需要。本研究旨在评估不同采样间隔下AIF启动时移和注射时间对GKM在DCE-MRI中生理参数估计的影响，并比较GKM与RRM的性能。通过计算机模拟，对时间分辨率分别为1、5和10 s的位移和分散AIF的K-trans、K-TOI和v（e，TOI）的平均误差（ME）和变异系数（CoV）进行了评估。在5-s的采样中，GKM的K-trans，K-TOI的最大ME约为22%，RRM为0.5%。在10秒的采样中，它们分别增加到28%和0.7%左右。所有病例V-e、V-TOI的最大MEs均在5%以下。但由于参考区域的信噪比较低，RRM得到的冠状病毒数均高于GKM。结果表明，与GKM相比，在时间分辨率较低的情况下，RRM对AIF启动时移和注射时间的敏感性相对较低。版权所有John Wiley & Sons， Ltd. 2009
In dynamic contrast-enhanced MR imaging (DCE-MRI), sampling of the arterial input function (AIF) is required for analysis using the general kinetic model (GKM). Alternatively, the recently proposed reference region model (RRM) may be employed to avoid the need of acquiring the AIF. This study aimed to evaluate the influence of the AIF onset-time shift and the injection duration, under various sampling intervals, on physiological parameter estimation in DCE-MRI using the GKM, and to compare the performance between GKM and RRM. Computer simulations were performed to assess the mean error (ME) and coefficient of variation (CoV) of K-trans,K-TOI and v(e,TOI) from shifted and dispersed AIF with temporal resolution of 1, 5 and 10 s. With 5-s sampling, the maximal ME of K-trans,K-TOI was roughly 22% for the GKM and 0.5% for the RRM. With 10-s sampling, they increased to around 28% and 0.7%, respectively. The maximal MEs of V-e,V-TOI for all cases were under 5%. However, owing to the lower SNR in the reference region, the CoV obtained by the RRM were all higher than those by the GKM. The results suggested that with compromised temporal resolution, the RRM was relatively less sensitive to the AIF onset-time shift and the injection duration compared with the GKM. Copyright (C) 2009 John Wiley & Sons, Ltd.