Multiresponsive Reversible Deformation of Patterned Polyacrylamide Hydrogel Constructed by a Computer-Assisted Dispenser
Multiresponsive Reversible Deformation of Patterned Polyacrylamide Hydrogel Constructed by a Computer-Assisted Dispenser
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DOI：
10.1021/acsapm.9b00196
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发表时间：
2019-04
影响因子：
5
通讯作者：
Xiao-Qin Zhang;Di Wu;Jun-Bo Hou;Jun-Feng Feng-Jun-Feng-Feng-2117000864;Duo Ke;S. Zhang;Bang‐Jing Li
中科院分区：
文献类型：
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作者：
Xiao-Qin Zhang;Di Wu;Jun-Bo Hou;Jun-Feng Feng-Jun-Feng-Feng-2117000864;Duo Ke;S. Zhang;Bang‐Jing Li
可变形的材料在生物医学领域具有潜在的应用前景，但如何通过简单的方法对水凝胶进行图案化并精确地编程目标三维（3D）形状一直是一个挑战。在这里，我们开发了一种简便的方法，允许制造不均匀的水凝胶，它可以可逆地从平面片变形到3D形状响应于多刺激，如pH值，SLDC（具有较低介电常数的溶液），和SBF（模拟体液）。通过在经典的PAAm水凝胶片上印刷NaOH溶液墨水，PAAm的酰胺侧基水解为丙烯酸酯。印刷和未印刷区域的溶胀失配产生内应力以激活水凝胶变形。通过调节NaOH溶液的浓度或印刷次数，可以方便地在水凝胶片上引入面内和贯穿厚度的梯度分布。喷墨打印过程易于计算机控制，可直接打印批量和批量产品。
Materials that can undergo shape deformation have potential applications in biomedical field, yet it has always been a challenge to pattern hydrogels and accurately program target three-dimensional (3D) shapes through a simple method. Here, we develop a facile method that permits fabrication of inhomogeneous hydrogels, which can reversibly deform from planar sheet to 3D shape in response to multistimuli, such as pH values, SLDC (solutions with lower dielectric constant), and SBF (simulated body fluid). By printing NaOH solution ink on classic PAAm hydrogel sheet, the amide side groups of PAAm hydrolyzed to acrylate. The swelling mismatch of the printed and unprinted areas generates internal stress to activate hydrogel deformation. Adjusting concentration of NaOH solution or number of times of printing, it is convenient to introduce in-plane and through-thickness gradient distribution to hydrogel sheet. The inkjet printing process is easily controlled by computer, enabling the direct printing of batched an...