EWINGS-SARCOMA OF BONE - CLINICOPATHOLOGIC ASPECTS OF 303 CASES FROM THE INTERGROUP EWINGS-SARCOMA STUDY
EWINGS-SARCOMA OF BONE - CLINICOPATHOLOGIC ASPECTS OF 303 CASES FROM THE INTERGROUP EWINGS-SARCOMA STUDY
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DOI：
10.1016/s0046-8177(83)80300-1
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发表时间：
1983-01-01
期刊：
影响因子：
3.3
通讯作者：
SHIRLEY, SF
中科院分区：
文献类型：
--
作者：
KISSANE, JM;ASKIN, FB;SHIRLEY, SF
描述了组间尤文氏肉瘤研究组收集的303例骨尤文氏肉瘤的临床病理特征。尤因氏肉瘤主要发生在 10-15 岁年轻白人患者的骨骼下段。在几种公认的组织学模式中，丝状模式（一种由薄膜状血管基质分隔的双细胞组织链组成的类器官模式）与最低的存活率相关。肿瘤细胞中细胞质糖原的光学显微镜证据对于诊断有用，但不是必需的。无论治疗方式如何，临床行为最重要的预测因素是主要受累部位。骨盆骨原发肿瘤患者的生存率最低，而四肢远端骨病变患者的生存率最高。
Clinicopathologic features of 303 cases of Ewing''s sarcoma of bone collected by the Intergroup Ewing''s Sarcoma Study group are described. Ewing''s sarcoma arose predominantly in the inferior segment of the skeleton in young white patients from 10-15 yr of age. Of the several recognized histologic patterns, the filagree pattern-an organoid pattern consisting of bicellular strands of tissue separated by filmy vascular stroma-was associated with the lowest survival rates. Light microscopic evidence of cytoplasmic glycogen in tumor cells was useful in but not requisite for diagnoses. The most important predictor of clinical behavior, regardless of treatment modality, was the site of primary involvement. Survival among patients with primary tumors in pelvic bones was lowest, whereas survival among patients with lesions in distal bones of the extremities was highest.