IMPAIRMENT OF SPATIAL BUT NOT CONTEXTUAL MEMORY IN CAMKII MUTANT MICE WITH A SELECTIVE LOSS OF HIPPOCAMPAL LTP IN THE RANGE OF THE THETA-FREQUENCY
IMPAIRMENT OF SPATIAL BUT NOT CONTEXTUAL MEMORY IN CAMKII MUTANT MICE WITH A SELECTIVE LOSS OF HIPPOCAMPAL LTP IN THE RANGE OF THE THETA-FREQUENCY
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DOI：
10.1016/0092-8674(95)90010-1
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发表时间：
1995-06-16
期刊：
影响因子：
64.5
通讯作者：
MAYFORD, M
中科院分区：
文献类型：
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作者：
BEACH, ME;HAWKINS, RD;MAYFORD, M
我们评估了在小鼠中的钙依赖性记忆与Ca 2+的非依赖性形式的CaMKII所产生的天冬氨酸在氨基酸286处的引入。CaMKII-Asp-286小鼠在高频刺激下表现出正常的LTP，但在5-10 Hz范围内，它们表现出有利于LTD的频率响应曲线的偏移。该频率范围与θ节律相似，这与啮齿动物的探索有关。使用巴恩斯迷宫来评估空间记忆，我们发现转基因小鼠不能学习使用空间线索导航到特定位置。相比之下，一组转基因小鼠在情境恐惧条件反射中表现正常，这也是一项海马依赖性任务。空间记忆和背景记忆的分离表明，尽管两者都需要海马体，但它们可能是由不同的突触机制介导的。
We assessed hippocampal-dependent memory in mice with a Ca2+-independent form of CaMKII generated by the introduction of an aspartate at amino acid 286. The CaMKII-Asp-286 mice show normal LTP at high frequency stimulation, but in the 5-10 Hz range, they show a shift in the frequency-response curve favoring LTD. This range of frequencies is similar to the theta rhythm, which is associated with exploration in rodents. Using the Barnes maze to assess spatial memory, we found the transgenic mice could not learn to navigate to a specific location using spatial cues. In contrast, one line of transgenic mice performed normally in contextual fear conditioning, a task that is also hippocampal dependent. This dissociation between spatial and contextual memory suggests that even though both require the hippocampus, they may be mediated by different synaptic mechanisms.