Increased neonatal fat mass, not lean body mass, is associated with maternal obesity
Increased neonatal fat mass, not lean body mass, is associated with maternal obesity
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DOI：
10.1016/j.ajog.2006.06.014
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发表时间：
2006-10-01
影响因子：
9.8
通讯作者：
Catalano, Patrick
中科院分区：
文献类型：
--
作者：
Sewell, Mark F.;Huston-Presley, Larraine;Catalano, Patrick
目的：本研究的目的是比较超重/肥胖妇女（体重指数，>= 25 kg/m(2)）与瘦/平均妇女（体重指数，< 25 kg/m(2)）新生儿的身体成分测量，所有这些妇女的糖耐量水平正常。研究设计：对妊娠前超重/肥胖孕妇单胎妊娠的76名新生儿（34名女性和42名男性）和144名消瘦/普通孕妇的新生儿（67名女性和77名男性）进行人体测量和出生时身体成分的全身电导率评估。结果：超重/肥胖组与瘦/平均体重组相比，出生体重（3436 +/- 567 g vs 3284 +/- 534 g; P = 0.051）有边缘性增加，但瘦体重（3020 +/- 410 g vs 2950 +/- 400 g; P = 0.23）没有。然而，超重/肥胖妇女的新生儿体脂率（11.6% +/- 4.7% vs 9.7 +/- 4.3%; P = 0.003）和脂肪量（420 +/- 220 g vs 380 +/- 170 g; P = 0.01）明显高于瘦/平均体重妇女。结论：糖耐量水平正常的超重/肥胖妇女，由于肥胖增加，其新生儿比瘦/平均体重妇女重。我们推测，糖耐量正常的肥胖妇女的后代肥胖增加是青少年肥胖和代谢综合征组成部分的重要风险。(c) 2006 Mosby, Inc。版权所有。
Objective: The purpose of this study was to compare body composition measures in neonates of women who were overweight/obese (body mass index, >= 25 kg/m(2)) versus women who were lean/average (body mass index, < 25 kg/m(2)), all of whom had normal glucose tolerance levels.Study design: Seventy-six neonates (34 female and 42 male) of singleton pregnancies of pregravid overweight/obese women and 144 neonates (67 female and 77 male) of lean/average women were assessed with anthropometric measures and total body electrical conductivity evaluation of body composition at birth.Results: There was a borderline increase in birthweight (3436 +/- 567 g vs 3284 +/- 534 g; P = .051) but not lean body mass (3020 +/- 410 g vs 2950 +/- 400 g; P = .23) in the overweight/obese versus lean/average weight groups. However, there were significant increases in percent body fat (11.6% +/- 4.7% vs 9.7 +/- 4.3%; P = .003) and fat mass (420 +/- 220 g vs 380 +/- 170 g; P = .01) in neonates of overweight/obese women versus lean/average weight women.Conclusion: Overweight/obese women with normal glucose tolerance levels have neonates who are heavier than lean/average weight women because of increased adiposity. We speculate that this increased obesity in offspring of obese women with normal glucose tolerance levels is a significant risk for adolescent obesity and components of the metabolic syndrome. (c) 2006 Mosby, Inc. All rights reserved.