The effects of electrical microstimulation on cortical signal propagation
The effects of electrical microstimulation on cortical signal propagation
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DOI：
10.1038/nn.2631
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发表时间：
2010-10-01
影响因子：
25
通讯作者：
Merkle, Hellmut
中科院分区：
文献类型：
--
作者：
Logothetis, Nikos K.;Augath, Mark;Merkle, Hellmut
电刺激已被用于动物和人类，以研究神经活动和特定认知功能之间的潜在因果关系。最近，它在电疗和神经假体中的应用越来越多。然而，电刺激引起的信号在脑组织中传播的方式仍然不清楚。我们采用联合电刺激，神经生理学，显微注射和功能磁共振成像（fMRI）研究皮质活动模式引起的刺激皮层传入在猴子。我们发现，刺激外侧膝状体核（LGN）中的一个部位会增加初级视觉皮层（V1）中接收该部位输入的区域的fMRI信号，但会抑制纹外皮层中视网膜定位匹配区域的fMRI信号。与之前的观察结果一致，颅内记录表明，刺激脉冲后立即发生短暂的兴奋性反应，随后是持久的抑制。在V1区微量注射GABA拮抗剂后，LGN刺激在所有皮层区域诱导了阳性fMRI信号。综上所述，我们的研究结果表明，电刺激干扰皮质-皮质信号传播沉默的任何新皮层区域的传入电刺激的输出。
Electrical stimulation has been used in animals and humans to study potential causal links between neural activity and specific cognitive functions. Recently, it has found increasing use in electrotherapy and neural prostheses. However, the manner in which electrical stimulation-elicited signals propagate in brain tissues remains unclear. We used combined electrostimulation, neurophysiology, microinjection and functional magnetic resonance imaging (fMRI) to study the cortical activity patterns elicited during stimulation of cortical afferents in monkeys. We found that stimulation of a site in the lateral geniculate nucleus (LGN) increased the fMRI signal in the regions of primary visual cortex (V1) that received input from that site, but suppressed it in the retinotopically matched regions of extrastriate cortex. Consistent with previous observations, intracranial recordings indicated that a short excitatory response occurring immediately after a stimulation pulse was followed by a long-lasting inhibition. Following microinjections of GABA antagonists in V1, LGN stimulation induced positive fMRI signals in all of the cortical areas. Taken together, our findings suggest that electrical stimulation disrupts cortico-cortical signal propagation by silencing the output of any neocortical area whose afferents are electrically stimulated.