Postnatal Weight and Height Growth Modeling and Prediction of Body Mass Index as a Function of Time for the Study of Growth Determinants
Postnatal Weight and Height Growth Modeling and Prediction of Body Mass Index as a Function of Time for the Study of Growth Determinants
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DOI：
10.1159/000362203
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发表时间：
2014-01-01
影响因子：
3.9
通讯作者：
Charles, Marie-Aline
中科院分区：
文献类型：
--
作者：
Botton, Jeremie;Scherdel, Pauline;Charles, Marie-Aline
体重、身高和体重指数（BMI）的增长轨迹与晚年的几种慢性疾病有关。我们的目的是描述一种方法来模拟婴儿期的个体体重和身高生长曲线，并展示如何将其用于研究其决定因素和与以后健康结果的关系，以及预测BMI轨迹。在EDEN母婴队列中，我们从1，900名婴儿的医疗保健手册中以及在1岁和3岁的研究临床检查期间收集了每个婴儿在出生至3岁期间的17项体重测量值和16项身长/身高测量值; 1，436人（76%）在2至3年间至少进行了1次测量。我们使用Jenss非线性模型拟合个体体重和身高生长轨迹，包括使用“SAEMIX”软件包（R软件）的随机效应。我们研究了个体生长模型参数是否与性别相关的一步和两步方法。我们间接计算BMI随时间的增长，体重和身高增长模型相结合，并比较了拟合与直接多级样条模型。通过对观察到的生长数据进行建模，我们将测量的数量和年龄方面的数据均化，并能够计算其他特定参数作为生长速度。(C)2014 S. Karger AG，巴塞尔
Weight, height and body mass index (BMI) growth trajectories have been associated with several chronic diseases in later life. Our aim was to describe a method to model individual weight and height growth curves during infancy and to show how it can be used to study their determinants and relationships with later health outcomes as well as to predict BMI trajectories. In the EDEN mother-child cohort, we collected 17 measurements of weight and 16 of length/height per child between birth and 3 years of age in 1,900 infants from their health care booklet and during the study clinical examinations at 1 and 3 years; 1,436 (76%) had at least 1 measurement between 2 and 3 years. We fitted individual weight and height growth trajectories using the Jenss non-linear model including random effects using the 'SAEMIX' package (R software). We studied whether individual growth model parameters were associated with gender in one- and two-step approaches. We indirectly calculated BMI increase against time from both weight and height growth models combined and compared the fit with a direct multilevel spline model. By modeling observed growth data, we homogenized the data in terms of number and age of measurements and were able to calculate other specific parameters as growth velocities. (C) 2014 S. Karger AG, Basel