Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.
Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.
复制标题
Elovl6 的消除可以保护胰岛免受高脂肪饮食引起的胰岛素分泌损伤。
DOI：
10.1016/j.bbrc.2014.05.113
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Shimano H.
中科院分区：
文献类型：
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作者：
Tang N;Matsuzaka T;Suzuki M;Nakano Y;Zao H;Yokoo T;Suzuki-Kemuriyama N; Kuba M;Okajima Y;Takeuchi Y;Kobayashi K;Iwasaki H;Yatoh S;Takahashi A;Suzuki H;Sone H;Shimada M;Nakagawa Y;Yahagi N;Yamada N;Shimano H.
Elov 16是一种微粒体酶，其调节C12-16饱和和单不饱和脂肪酸的延伸，并通过脂肪酸组成的改变与肥胖诱导的胰岛素抵抗的发展相关。在这项研究中，我们研究了全身性Elovl 6在胰岛和β细胞功能中的作用。Elovl 6在胰岛和β细胞系中表达。在喂食食物的小鼠中，与野生型小鼠相比，Elov 16 −/−小鼠的胰岛显示出正常的结构和β细胞质量。然而，当喂食高脂肪、高蔗糖（HFHS）饮食时，在正常小鼠中观察到的响应胰岛素抵抗的胰岛肥大被减弱，并且Elovl 6-/-小鼠的胰岛中葡萄糖刺激的胰岛素分泌（GSIS）增加与野生型小鼠相比。HFHSElov 16 −/−胰岛中GSIS的增强与ATP/ADP比率的增加和ATF-3表达的抑制有关。我们的研究结果表明Elov 16可能参与每个β细胞的胰岛素分泌能力和糖尿病。
ELOVL family member 6, elongation of very long-chain fatty acids (Elovl6) is a microsomal enzyme that regulates the elongation of C12–16 saturated and monounsaturated fatty acids and is related to the development of obesity-induced insulin resistance via the modification of the fatty acid composition. In this study, we investigated the role of systemic Elovl6 in the pancreatic islet and β-cell function. Elovl6 is expressed in both islets and β-cell lines. In mice fed with chow, islets of theElovl6−/−mice displayed normal architecture and β-cell mass compared with those of the wild-type mice. However, when fed a high-fat, high-sucrose (HFHS) diet, the islet hypertrophy in response to insulin resistance observed in normal mice was attenuated and glucose-stimulated insulin secretion (GSIS) increased in the islets ofElovl6−/−mice compared with those of the wild-type mice. Enhanced GSIS in the HFHSElovl6−/−islets was associated with an increased ATP/ADP ratio and the suppression of ATF-3 expression. Our findings suggest that Elovl6 could be involved in insulin secretory capacity per β-cell and diabetes.