Epidemiology of Celiac Disease
Epidemiology of Celiac Disease
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DOI：
10.1016/j.gtc.2018.09.004
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发表时间：
2019-03-01
影响因子：
3.7
通讯作者：
Murray, Joseph A.
中科院分区：
文献类型：
--
作者：
Ludvigsson, Jonas F.;Murray, Joseph A.
乳糜泻是一种常见的慢性小肠炎性疾病，由特定基因类型的人暴露于面筋引起。这种疾病影响到任何年龄或性别的人。尽管人们通常认为它起源于欧洲，但现在它的影响范围是全球的。表现形式多种多样，从无症状的患者到严重营养不良。最初的检测通常依赖于特定于腹腔的血清学，而确诊通常需要肠道活检。在过去20年里，由于几乎肯定是环境原因，发病率和发病率大幅增加，但其原因尚不清楚。
Celiac disease is a common, chronic inflammatory disorder of the small intestine triggered by exposure to gluten in individuals with certain genetic types. This disorder affects people of any age or gender. Although often thought to be European in origin, it is now global in extent. Presentations are variable, from asymptomatic patients to severe malnutrition. Initial detection usually relies on celiac-specific serology, and confirmation often requires intestinal biopsy. There have been substantial increases in prevalence and incidence over the last 2 decades for reasons that are almost certainly environmental but for which there is no clarity as to cause.