Morphine administration selectively facilitates social play in common marmosets
Morphine administration selectively facilitates social play in common marmosets
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DOI：
10.1002/dev.10043
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发表时间：
2002-07-01
影响因子：
2.2
通讯作者：
Roberts, RL
中科院分区：
文献类型：
--
作者：
Guard, HJ;Newman, JD;Roberts, RL
普通狨猴（Callithrix jacchus）形成大家庭，几群幼猴可能生活在一起，后代中广泛地表现出玩耍的行为。我们假设阿片类药物活性调节社交游戏，并预测给予吗啡（0.5 毫克/千克）会促进社交游戏，而纳洛酮（0.5 毫克/千克）预处理会阻止吗啡的作用。吗啡给药与社交游戏的显着增加有关，并且吗啡的效果可归因于焦点对象，因为其他人发起的游戏不受治疗影响。非社交类别的游戏，例如物体操纵和运动游戏，以及亲和行为，例如挤在一起的时间，如果不受治疗影响的话。服用吗啡后，年轻人在玩耍时使用的推特和玩脸行为也有所增加。纳洛酮预处理可阻断吗啡的作用。吗啡给药后总活性显着增加。我们得出的结论是，阿片类药物的激活特别促进了社交游戏，而其他类别的游戏行为和社交行为则不受吗啡的影响。因此，社交游戏代表了幼年普通狨猴的一种独特的社会行为，其调节过程不同于其他类型的社会行为。出版 (C) 2002 Wiley periodicals, Inc.
Common marmosets (Callithrix jacchus) form extended families, and several cohorts of young may reside together Play is shown extensively among the offspring. We hypothesized that opiate activity modulates social play, and predicted that administration of morphine (0.5 mg/kg) would facilitate social play, whereas pretreatment with naloxone (0.5 mg/kg) would block morphine's effects. Morphine administration was associated with significantly increased socialplay, and the effect of morphine was attributable to the focal subject, since play initiated by others was unaffected by treatment. Non-social categories of play, such as object manipulation and locomotor play, and affiliative behaviors, such as time spent huddled, were it unaffected by treatment. Twittering and play face, behaviors used by young during play, also increased after morphine administration. Pretreatment with naloxone blocked morphine's effects. Total activity was significantly increased by morphine administration. We conclude that social play is specifically facilitated by opiate activation, whereas other categories of play behavior and social behavior were unaffected by morphine. Thus, social play represents a distinct category of social behavior in juvenile common marmosets with regulatory processes that are unique from other types of social behavior. Published (C) 2002 Wiley Periodicals, Inc.