Characterization of the Soluble fms-Like Tyrosine Kinase-1 to Placental Growth Factor Ratio in Pregnancies Complicated by Fetal Growth Restriction
Characterization of the Soluble fms-Like Tyrosine Kinase-1 to Placental Growth Factor Ratio in Pregnancies Complicated by Fetal Growth Restriction
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DOI：
10.1097/aog.0000000000000367
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发表时间：
2014-08-01
影响因子：
7.2
通讯作者：
Verlohren, Stefan
中科院分区：
文献类型：
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作者：
Herraiz, Ignacio;Droege, Lisa Antonia;Verlohren, Stefan
目的：探讨可溶性FMS样酪氨酸激酶-1(sFlt-1)与胎盘生长因子(PlGF)比值在胎儿期生长受限伴或不伴先兆子痫或溶血、肝酶升高及低血小板综合征(HELLP)中的价值，以及与171例正常妊娠配对的单胎妊娠合并胎儿生长受限(n=27)、子痫前期或HELLP(n=105)、子痫前期或HELLP(n=39)和胎儿生长受限(n=171)的病例对照研究。对确诊后的孕妇血清标本和胎龄匹配的健康对照标本进行sFlt-1和PlGF的自动检测。结果：胎儿生长受限、先兆子痫或HELLP、先兆子痫或HELLP合并胎儿生长受限孕妇在孕34周前sFlt1/PlGF比值的中位数均高于对照组(分别为90、231、514和3，P
OBJECTIVE: To characterize the values of the soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio in pregnancies with fetal growth restriction with or without concurrent preeclampsia or hemolysis, elevated liver enzymes and low platelets syndrome (HELLP) and in pregnancies with normally grown fetuses with or without concurrent preeclampsia or HELLP.METHODS: This is a case-control study performed in two centers (Berlin and Madrid) consisting of 171 singleton pregnancies complicated by fetal growth restriction (n=27), preeclampsia or HELLP (n=105) or preeclampsia or HELLP and fetal growth restriction (n=39) pairwise matched by gestational age with 171 healthy control pregnancies. Automated measurement of sFlt-1 and PlGF in maternal serum samples was performed after diagnosis (cases) and in gestational-age matched healthy control samples. Samples were analyzed for two timeframes: before and at or after 34 weeks of gestation.RESULTS: Pregnancies with fetal growth restriction, preeclampsia or HELLP, and preeclampsia or HELLP and fetal growth restriction showed higher median values of sFlt1/PlGF ratio than control pregnancies both before 34 weeks of gestation (90, 231, 514, and 3, respectively, P