Effects of gonadal steroids on melanocytes in developing hamsters.
Effects of gonadal steroids on melanocytes in developing hamsters.
复制标题
性腺类固醇对发育中仓鼠黑素细胞的影响。
DOI：
10.1111/j.1525-1470.1986.tb00522.x
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发表时间：
1986
影响因子：
1.5
通讯作者：
Beattie,CW
中科院分区：
文献类型：
--
作者：
Diaz,LC;DasGupta,TK;Beattie,CW
从形态计量学的角度分析了长期给予5-α-双氢睾酮和17-雌二醇-β对正常和去垂体期雄性叙利亚仓鼠背侧肋椎斑点和阴囊皮肤的影响。5α-双氢睾酮增加了肋椎斑点和阴囊皮肤的色素沉着(光密度)，但不改变完整动物的色素面积百分比。去垂体的仓鼠的斑点大小和色素密度也显著增加，但着色面积的百分比没有变化。5α-双氢睾酮不改变去垂体动物阴囊皮肤任何区域的色素沉着百分比。相反，在完整的动物中，雌二醇产生与剂量相关的阴囊皮肤黑素细胞的数量减少。雄激素引起的肋颈斑毛囊色素沉着的增加可被雌激素逆转，雌激素增加了皮脂腺周围的色素沉着。这些观察表明，雄性仓鼠对色素沉积的雄激素刺激是直接的，发生在青春期之前，可能是组织特异性的，并被雌激素拮抗。毛囊附近和皮脂腺周围的黑素细胞对这些类固醇的不同反应可能是由于前黑色素氧化状态的改变，黑素细胞大小和形状的改变，或者黑色素合成速度的实际改变。
The effects of chronically administered 5α‐dihydrotestosterone and estradiol‐17β on the dorsal costovertebral spots and scrotal skin of intact and hypophysectomized prepubertal male Syrian hamsters were analyzed morphometrically. The 5α‐dihydrotestosterone increased pigmentation (optical density) of costovertebral spots and scrotal skin without altering the percentage of pigmented area in intact animals. Spot size and pigment density also increased significantly in hypophysectomized hamsters, but there was no change in the percentage of pigmented area. The 5α‐dihydrotestosterone did not alter the percentage of pigmentation in any area of scrotal skin in hypophysectomized animals. In contrast, estradiol produced a dose‐related decrease in the number of scrotal skin melanocytes in intact animals. The androgen‐induced increase in pigmentation of costovertebral spot hair follicles was reversed by estradiol, which increased pigmentation around the sebaceous glands. These observations suggest that androgenic stimulation of pigmentation in male hamsters is direct, takes place prior to puberty, is probably tissue specific, and is antagonized by estrogens. The differential response to these steroids of melanocytes adjacent to hair follicles and around the perimeter of sebaceous glands may result from changes in the oxidation state of premelanin, an alteration in melanocyte size and shape, or an actual change in the rate of melanin synthesis.