Frequency of analgesic use and risk of hypertension in younger women
Frequency of analgesic use and risk of hypertension in younger women
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DOI：
10.1001/archinte.162.19.2204
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发表时间：
2002-10-28
影响因子：
--
通讯作者：
Stampfer, M
中科院分区：
文献类型：
--
作者：
Curhan, GC;Willett, WC;Stampfer, M
背景：镇痛药除了具有解热、抗炎和镇痛作用外，还可能干扰血压调节。然而，很少有前瞻性的信息是可用的镇痛药的使用和高血压的风险之间的关联。方法：我们进行了一项前瞻性研究，80 020名妇女，年龄在31至50岁，谁参加了护士的健康研究II，以前没有高血压的历史。1995年通过邮寄问卷收集阿司匹林、非甾体抗炎药（NSAID）和对乙酰氨基酚的使用频率（每月天数）。通过1997年两年一次的问卷调查确定了医生诊断的高血压事件病例。结果：在164090人年的随访中，确定了1650例高血压事件病例。至少1天/月，51.2%的队列使用阿司匹林，76.7%使用NSAID，72.5%使用对乙酰氨基酚。调整年龄后，所有3类镇痛药均与高血压事件风险增加相关（P
Background: In addition to their antipyretic, anti-inflammatory, and pain-relieving effects, analgesics may interfere with blood pressure regulation. However, little prospective information is available on the association between analgesic use and the risk of hypertension.Methods: We performed a prospective study of 80 020 women aged 31 to 50 years who participated in the Nurses' Health Study II and had no previous history of hypertension. Frequency of use (in days per month) of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen was collected by mailed questionnaire in 1995. Incident cases of physician-diagnosed hypertension were identified by self-report on the 1997 biennial questionnaire.Results: During 164 090 person-years of follow-up, 1650 incident cases of hypertension were identified. At least 1 d/mo, 51.2% of the cohort used aspirin, 76.7% used NSAIDs, and 72.5% used acetaminophen. After adjusting for age, all 3 classes of analgesics were associated with an increased risk of incident hypertension (P