Application of quercetin in neurological disorders: from nutrition to nanomedicine
Application of quercetin in neurological disorders: from nutrition to nanomedicine
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DOI：
10.1515/revneuro-2018-0080
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发表时间：
2019-07-01
影响因子：
4.1
通讯作者：
Nourbakhshnia, Maryam
中科院分区：
文献类型：
--
作者：
Amanzadeh, Elnaz;Esmaeili, Abolghasem;Nourbakhshnia, Maryam
槲皮素是一种多酚类黄酮，常见于水果和蔬菜中。槲皮素的抗氧化潜力已经从亚细胞区室（即线粒体）到大脑中的组织水平进行了研究。神经变性过程伴随着神经元的老化而开始。它出现在大脑的不同部位，如A β斑块、神经元缠结、路易体、皮克体等，导致阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩性侧索硬化症和其他疾病。到目前为止，还没有针对这些疾病的具体治疗方法。尽管常见的治疗有助于预防疾病的发展，但患有进行性神经退行性疾病的患者的病情通常不会完全改善。目前，类黄酮，特别是槲皮素用于治疗神经退行性疾病的用途已经在动物模型中得到了扩展。它也被用于治疗神经退行性疾病的动物模型。此外，还观察到行为水平以及细胞和分子水平的改善，抗氧化剂和凋亡蛋白的活性降低，抗凋亡蛋白的水平增加。槲皮素的低生物利用度也导致研究人员构建各种槲皮素相关的纳米颗粒。使用涉及槲皮素的纳米颗粒治疗神经变性的动物模型已经表明，在较短的时间内和使用较低的浓度下观察到改善。事实上，鼻内给药槲皮素涉及的纳米粒子，构建超顺磁性纳米粒子，并使用纳米粒子，如槲皮素和其他药物的组合治疗建议为未来的研究。
Quercetin is a polyphenolic flavonoid, which is frequently found in fruits and vegetables. The antioxidant potential of quercetin has been studied from subcellular compartments, that is, mitochondria to tissue levels in the brain. The neurodegeneration process initiates alongside aging of the neurons. It appears in different parts of the brain as A beta plaques, neurofibrillary tangles, Lewy bodies, Pick bodies, and others, which leads to Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and other diseases. So far, no specific treatment has been identified for these diseases. Despite common treatments that help to prevent the development of disease, the condition of patients with progressive neurodegenerative diseases usually do not completely improve. Currently, the use of flavonoids, especially quercetin for the treatment of neurodegenerative diseases, has been expanded in animal models. It has also been used to treat animal models of neurodegenerative diseases. In addition, improvements in behavioral levels, as well as in cellular and molecular levels, decreased activity of antioxidant and apoptotic proteins, and increased levels of antiapoptotic proteins have been observed. Low bioavailability of quercetin has also led researchers to construct various quercetin-involved nanoparticles. The treatment of animal models of neurodegeneration using quercetin-involved nanoparticles has shown that improvements are observed in shorter periods and with use of lower concentrations. Indeed, intranasal administration of quercetin-involved nanoparticles, constructing superparamagnetic nanoparticles, and combinational treatment using nanoparticles such as quercetin and other drugs are suggested for future studies.