Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance
Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance
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DOI：
10.1530/eje.0.1490331
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发表时间：
2003-10-01
影响因子：
5.8
通讯作者：
Murphy, LJ
中科院分区：
文献类型：
--
作者：
Silha, JV;Krsek, M;Murphy, LJ
目的：脂肪组织通过循环脂肪细胞因子、瘦素、抵抗素和脂联素调节胰岛素敏感性。本研究的目的是比较瘦和肥胖受试者的抵抗素、脂联素和瘦素水平，并确定循环脂肪细胞因子与胰岛素抵抗之间的关系。方法：我们检测了17名平均体重指数（BMI）接近23的瘦受试者和34名平均体重指数接近33的非糖尿病肥胖者的血浆抵抗素、脂联素和瘦素水平。胰岛素抵抗的评估使用稳态模型评估比率（HOMA-R）公式，该公式来源于空腹胰岛素和葡萄糖水平。结果：抵抗素水平在两组间无显著差异，但女性明显高于男性，为35.4 +/- 6.5 (S.E.) vs 15.4 +/- 2.9马克杯/升，P < 0.01。抵抗素与BMI无相关性，但与HOMA-R显著相关，P < 0.01，且在调整性别和BMI后，这种相关性仍然显著。肥胖组脂联素水平明显低于瘦子组（P < 0.005），女性组脂联素水平明显高于瘦子组（P < 0.001），但与HOMA-R无显著相关性。肥胖受试者和女性的瘦素水平明显更高，并且与HOMA-R和抵抗素相关。讨论：在这一小群患者中，我们证明了胰岛素抵抗与瘦素水平的相关性最强。抵抗素水平与胰岛素抵抗之间也有显著的相关性。虽然脂联素有类似的趋势，但与胰岛素抵抗的相关性不具有统计学意义。
Objective: Adipose tissue regulates insulin sensitivity via the circulating adipocytokines, leptin, resistin and adiponectin. The objective of this study was to compare the levels of resistin, adiponectin and leptin in lean and obese subjects and determine the relationship between circulating adipocytokines and insulin resistance.Methods: We examined plasma levels of resistin, adiponectin and leptin in 17 lean subjects with a mean body mass index (BMI) of similar to23 and 34 non-diabetic obese individuals with a mean BMI similar to33. Insulin resistance was assessed using the homeostasis model assessment ratio (HOMA-R) formula derived from fasting insulin and glucose levels.Results: Resistin levels were not significantly different between the two groups but were significantly higher in women compared with men, 35.4 +/- 6.5 (S.E.) vs 15.4 +/- 2.9 mug/l, P < 0.01. Resistin did not correlate with BMI but did significantly correlate with HOMA-R, P < 0.01, and this correlation remained significant after adjustment for gender and BMI. Adiponectin levels were significantly lower in obese compared with lean subjects, P < 0.005, and higher in women, P < 0.001, but showed no significant correlation with HOMA-R. Leptin levels were significantly higher in obese subjects and women and correlated with HOMA-R and resistin.Discussion: In this small group of patients we demonstrated that insulin resistance correlated most strongly with leptin levels. A significant correlation between resistin levels and insulin resistance was also observed. Although a similar trend was apparent for adiponectin, the correlation with insulin resistance did not achieve statistical significance.