Comparative effects of inotropic agents on coronary and systemic hemodynamics of conscious dogs: actions of milrinone, dopamine, ouabain and MCI-154.
Comparative effects of inotropic agents on coronary and systemic hemodynamics of conscious dogs: actions of milrinone, dopamine, ouabain and MCI-154.
复制标题
正性肌力药物对清醒狗冠状动脉和全身血流动力学的比较影响：米力农、多巴胺、哇巴因和 MCI-154 的作用。
DOI：
10.1159/000138388
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发表时间：
1988
期刊：
影响因子：
3.1
通讯作者：
Warltier,DC
中科院分区：
文献类型：
--
作者：
Al-Wathiqui,MH;Shimshak,TM;Brooks,HL;Preuss,KC;Wynsen,JC;Gross,GJ;Warltier,DC
一种新的正性肌力药物MCI-154的血流动力学作用进行了比较，多巴胺，哇巴因和米力农在清醒的，长期仪器狗。MCI-154和米力农产生了类似的血流动力学变化：心率、舒张期冠状动脉血流速度和峰值正dP/dt增加。两种药物均未对动脉压产生显著影响，而两种药物均以剂量相关方式降低左心室舒张末期压和心肌节段长度，表明舒张期左心室尺寸减小。MCI-154的效力约为米力农的两倍。相比之下，多巴胺和哇巴因产生的左心室舒张末期压或心肌段长度在阿托洛尔的变化不大，而这两种药物产生的动脉和左心室收缩压的增加。MCI-154或米力农均未观察到左心室后负荷增加，这突出了后者化合物的重要优势。
The hemodynamic actions of a new inotropic agent, MCI-154, were compared to dopamine, ouabain and milrinone in conscious, chronically instrumented dogs. MCI-154 and milrinone produced similar hemodynamic changes: increases in heart rate, diastolic coronary blood flow velocity and peak positive dP/dt. Neither agent had significant effects on arterial pressure while both drugs reduced left ventricular end-diastolic pressure in a dose-related fashion and myocardial segment length, indicating a decrease in diastolic left-ventricular size. MCI-154 was found to be approximately twice as potent as milrinone. In contrast, dopamine and ouabain produced little change in left ventricular end-diastolic pressure or myocardial segment length during diastole, while both drugs produced increases in arterial and left ventricular systolic pressures. An increase in left ventricular afterload was not observed with either MCI-154 or milrinone, highlighting an important advantage of the latter compounds.