The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis.
The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis.
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DOI：
10.1186/s41232-017-0050-9
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发表时间：
2017
影响因子：
8.1
通讯作者：
Takahashi M
中科院分区：
文献类型：
--
作者：
Karasawa T;Takahashi M
动脉粥样硬化是一种炎症性疾病，伴随着富含胆固醇的脂质沉积和巨噬细胞浸润。动脉粥样硬化病变的其他众所周知的特征包括胆固醇晶体和磷酸钙晶体的沉积;然而，它们的病理生理作用仍不清楚。最近的研究表明，胆固醇晶体在动脉粥样硬化病变中NLRP 3炎性体的激活中起关键作用，NLRP 3炎性体调节caspase-1的激活和随后的IL-1β的加工。NLRP 3炎性小体对于动脉粥样硬化进展期间血管炎症的起始是必不可少的。因此，NLRP 3炎性体的调节机制被认为是动脉粥样硬化治疗的潜在靶点。在此，我们回顾了目前关于NLRP 3炎性小体在动脉粥样硬化进展中的作用的知识，以及靶向NLRP 3炎性小体的治疗方法的前景。
Atherosclerosis is an inflammatory disease, which is accompanied by the deposition of cholesterol-rich lipids and the infiltration of macrophages. Other well-known features of atherosclerotic lesions include the deposition of cholesterol crystals and calcium phosphate crystals; however, their pathophysiological role remains unclear. Recent studies suggest that cholesterol crystals play a pivotal role in activation of NLRP3 inflammasomes, which regulate caspase-1 activation and the subsequent processing of IL-1β, in atherosclerotic lesions. NLRP3 inflammasomes are essential for the initiation of vascular inflammation during the progression of atherosclerosis. Therefore, the regulatory mechanisms of NLRP3 inflammasomes are regarded as potential targets for atherosclerosis treatment. Here, we review the current knowledge regarding the role of NLRP3 inflammasomes in the progression of atherosclerosis and the prospects for therapeutic approaches targeting NLRP3 inflammasomes.