The dynamics of acute inflammation
The dynamics of acute inflammation
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DOI：
10.1016/j.jtbi.2004.04.044
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发表时间：
2004-09-21
影响因子：
2
通讯作者：
Chow, CC
中科院分区：
文献类型：
--
作者：
Kumar, R;Clermont, G;Chow, CC
当身体被感染时，它会产生急性炎症反应，以清除病原体并恢复健康。感染引起的不受控制的急性炎症在临床上被定义为脓毒症，并可最终导致器官衰竭和死亡。我们考虑一个三维常微分方程模型的炎症组成的病原体，和两个炎症介质。该模型再现了健康的结果和不同的负面结果，这取决于初始条件和参数。我们分析了关键参数改变时不同结局之间的各种分歧，并提出了各种治疗策略。我们认为脓毒症的临床状况可以由几种不同的生理状态引起，每种状态都需要不同的治疗方法。爱思唯尔有限公司出版
When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as sepsis and can culminate in organ failure and death. We consider a three-dimensional ordinary differential equation model of inflammation consisting of a pathogen, and two inflammatory mediators. The model reproduces the healthy outcome and diverse negative outcomes, depending on initial conditions and parameters. We analyze the various bifurcations between the different outcomes when key parameters are changed and suggest various therapeutic strategies. We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach. Published by Elsevier Ltd.