CANINE EXPOSURE TO BORRELIA-BURGDORFERI AND PREVALENCE OF IXODES-DAMMINI (ACARI, IXODIDAE) ON DEER AS A MEASURE OF LYME-DISEASE RISK IN THE NORTHEASTERN UNITED-STATES
CANINE EXPOSURE TO BORRELIA-BURGDORFERI AND PREVALENCE OF IXODES-DAMMINI (ACARI, IXODIDAE) ON DEER AS A MEASURE OF LYME-DISEASE RISK IN THE NORTHEASTERN UNITED-STATES
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DOI：
10.1093/jmedent/30.1.171
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发表时间：
1993-01-01
影响因子：
2.1
通讯作者：
LAPOINTE, DA
中科院分区：
文献类型：
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作者：
DANIELS, TJ;FISH, D;LAPOINTE, DA
与依赖任何单一方法的程序，特别是人类病例报告相比，识别媒介(达米尼硬蜱)和病原体(伯氏疏螺旋体)存在的区域的监测程序可以更早、更准确地识别莱姆病及其传播的风险。1989年秋天，对马里兰州、马萨诸塞州、新罕布夏州、纽约州和宾夕法尼亚州22个县的猎杀鹿(n=1,204头)进行了检查，并确定了所有体外寄生虫。第二年春天，从这些地点(包括已知的流行区和莱姆病不常见的地区)获得犬血清(n=884)，并用酶联免疫吸附试验进行检测。对来自同一县的鹿的犬类血清阳性率与扁虱患病率的回归分析表明，两者之间存在显著的正向线性关系。根据地点在回归曲线上的位置，将地点指定为低风险、中等风险或高风险县。这些地点的地理分布与已知的莱姆病流行区和非流行区的分布很好地相关。还确定了莱姆病可能出现的地点。在这项研究中确定的病媒和病原体丰度测量之间的正相关关系使公共卫生工作者能够独立于人间病例报告来确定流行和潜在流行地区。
Surveillance programs that identify areas where both the vector (Ixodes dammini) and etiologic agent (Borrelia burgdorferi) are present may identify the risk of Lyme disease and its spread earlier and more accurately than do programs relying on any single method, particularly human case reports. Hunter-killed deer (n = 1,204) from 22 counties in Maryland, Massachusetts, New Hampshire, New York, and Pennsylvania were examined in fall 1989 and all ectoparasites were identified. The following spring, canine sera (n = 884) were obtained from these sites, which included known endemic areas and those where Lyme disease is uncommon, and tested by enzyme-linked immunosorbent assay. Regression analysis of canine seroprevalence versus tick prevalence on deer from the same counties demonstrate a significant positive linear relationship. Sites were designated as low-, moderate-, or high-risk counties based upon their position on the regression curve. The geographic distribution of the sites correlated well with the distribution of known Lyme disease endemic and nonendemic areas. Locations were also identified where Lyme disease may be emerging. The positive relationship between measures of vector and pathogen abundance determined in this study permits public health workers to identify endemic and potentially endemic areas independently of human case reports.