The Association between Diffuse Myocardial Fibrosis on Cardiac Magnetic Resonance T1 Mapping and Myocardial Dysfunction in Diabetic Rabbits.
The Association between Diffuse Myocardial Fibrosis on Cardiac Magnetic Resonance T1 Mapping and Myocardial Dysfunction in Diabetic Rabbits.
复制标题
糖尿病兔心脏磁共振T1图弥漫性心肌纤维化与心肌功能障碍的关系
DOI：
10.1038/srep44937
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发表时间：
2017-03-24
影响因子：
4.6
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Zeng M;Qiao Y;Wen Z;Liu J;Xiao E;Tan C;Xie Y;An J;Zhang Z;Fan Z;Li D
本研究的目的是评估弥漫性纤维化的影像替代物与心肌功能障碍之间的关系。新西兰大白兔36只，随机分为对照组(n = 18只)和四氧嘧啶糖尿病(DM)组(n = 18只)。对所有兔进行常规超声、二维斑点追踪和心脏磁共振(CMR)T1图检查，然后处死所有兔进行Masson‘s染色。根据增强前后T1值计算细胞外体积(ECV)，并与超声心动图测量的心肌功能进行皮尔逊相关分析。DM组ECV随病程延长而增加，与病理证实的心肌纤维化改变相一致。此外，ECV与舒张期早期应变率高度相关(r = −0.782，p <； 0.001)，与径向收缩峰值应变中度相关(r = 0.478，p = 0.045)。因此，ECV是CMR成像上心肌弥漫性纤维化的有效替代指标，ECV值越高，心肌舒张期功能损害越严重。
The objective of this study was to assess the relationship between imaging surrogates for diffuse fibrosis and myocardial dysfunction. Thirty-six New Zealand white rabbits were classified into two groups: a control group (n = 18) and an alloxan-induced diabetes mellitus (DM) group (n = 18). For all rabbits, conventional ultrasonography, two-dimensional speckle tracking, and cardiac magnetic resonance (CMR) T1 mapping were performed; all of the rabbits were then sacrificed for Masson’s staining. The extracellular volume (ECV) was calculated from pre- and post-contrast T1 values and compared with myocardial function measured by echocardiography using Pearson’s correlation. In the DM group, ECV increased as the duration of diabetes increased, consistent with the changes in myocardial fibrosis verified by pathology. Moreover, ECV was strongly correlated with the early diastolic strain rate (r = −0.782, p < 0.001) and moderately correlated with the radial systolic peak strain (r = 0.478, p = 0.045). Thus, ECV is an effective surrogate for myocardial diffuse fibrosis on CMR imaging, and higher ECV values are associated with an increased impairment of myocardial diastolic function.