Effects of Growth Hormone on the Lipolytic Response of Adipose Tissue to Theophylline1
Effects of Growth Hormone on the Lipolytic Response of Adipose Tissue to Theophylline1
复制标题
生长激素对脂肪组织对茶碱脂解反应的影响1
DOI：
10.1210/endo-82-5-1027
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发表时间：
1968
期刊：
影响因子：
4.8
通讯作者：
H. Goodman
中科院分区：
文献类型：
--
作者：
H. Goodman
垂体切除大鼠的脂肪组织对茶碱和其他脂解剂的反应能力降低。单次注射生长激素（100 μg）后3小时，茶碱引起的FFA和甘油产生增加，但基础脂解没有变化。脂肪组织在0.01-1.0 μg/ml生长激素存在下预孵育3小时，可显著增加对茶碱的脂解反应，同样不影响脂解的基础速率。生长激素的这种作用有一个超过1小时的滞后期，被胰岛素阻断，并被地塞米松增强，地塞米松具有类似但不太一致的作用。放线菌素不能阻断这种对生长激素的反应，放线菌酮能显著增强这种反应。这些数据被认为说明了生长激素对脂肪组织中3′，5 ′-环AMP水平的影响，并提出了生长激素对脂解的“许可”效应的生物化学解释。（内分泌...
Adipose tissue from hypophysectomized rats has a reduced capacity to carry on lipolysis in response to theophylline and other lipolytic agents. Three hr after a single injection of growth hormone (100 μg), FFA and glycerol production in response to theophylline are increased, but basal lipolysis is unchanged. Preincubation of adipose tissue for 3 hr in the presence of 0.01–1.0 μg/ml of growth hormone significantly increased the lipolytic response to theophylline, again without affecting the basal rate of lipolysis. This action of growth hormone has a lag period of more than 1 hr, is blocked by insulin and augmented by dexamethasone, which has a similar, but less consistent effect. Actinomycin failed to block this response to growth hormone and cycloheximide significantly enhanced it. These data are thought to illustrate an effect of growth hormone on the level of 3′,5′-cyclic AMP in adipose tissue, and suggest a biochemical explanation for the “permissive” effect of growth hormone on lipolysis. (Endocrino...