Indocyanine green (ICG) fluorescent cholangiography during laparoscopic cholecystectomy using RUBINA™ technology: preliminary experience in two pediatric surgery centers.
Indocyanine green (ICG) fluorescent cholangiography during laparoscopic cholecystectomy using RUBINA™ technology: preliminary experience in two pediatric surgery centers.
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DOI：
10.1007/s00464-021-08596-7
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Escolino M
中科院分区：
文献类型：
--
作者：
Esposito C;Alberti D;Settimi A;Pecorelli S;Boroni G;Montanaro B;Escolino M
最近，我们报道了吲哚菁绿（ICG）近红外荧光（NIRF）成像在儿科患者腹腔镜胆囊切除术（LC）期间识别肝外胆道解剖结构的可行性。本文旨在描述使用新技术 RUBINA™ 在儿科 LC 中进行术中 ICG 荧光胆管造影 (FC)。去年，两个儿科手术室使用新技术 RUBINA™ 在 LC 期间进行了 ICG-FC。 ICG 剂量为 0.35 mg/Kg，中位给药时间为手术前 15.6 小时。评估患者基线、术中细节、胆道解剖识别率、使用难易程度和手术结果。 13 名患者（11 名女孩）使用新的 RUBINA™ 技术接受了 LC，手术时的中位年龄为 12.9 岁。六名患者（46.1%）有相关合并症，五名患者（38.5%）正在接受药物治疗。术前检查包括超声（n = 13）和胆管MRI（n = 5），排除胆道和/或血管解剖异常。一名患者需要转为开放手术，因此被排除在研究之外。中位手术时间为 96.9 分钟（范围 55-180 分钟）。 2/12 名患者 (16.7%) 发生术中 ICG-NIRF 可视化技术失败。在其他病例中，ICG-NIRF 能够识别 4/12 (33.3%) 的胆管/血管解剖异常，包括右肝动脉莫伊尼汉驼峰 (n = 1)、囊上胆管 (n = 1) 和短胆囊管 (n = 2)。未报告对 ICG 过敏或不良反应、术后并发症或再次手术。我们的初步经验表明，新的 RUBINA™ 技术对于儿科患者 LC 期间进行 ICG-FC 非常有效。该技术的优点包括可以将 ICG-NIRF 数据叠加到标准白光图像上，并为外科医生提供目标解剖结构的持续荧光成像，以评估关键胆道结构的位置或解剖异常的存在并安全地进行手术。在线版本包含可在 10.1007/s00464-021-08596-7 获取的补充材料。
Recently, we reported the feasibility of indocyanine green (ICG) near-infrared fluorescence (NIRF) imaging to identify extrahepatic biliary anatomy during laparoscopic cholecystectomy (LC) in pediatric patients. This paper aimed to describe the use of a new technology, RUBINA™, to perform intra-operative ICG fluorescent cholangiography (FC) in pediatric LC. During the last year, ICG-FC was performed during LC using the new technology RUBINA™ in two pediatric surgery units. The ICG dosage was 0.35 mg/Kg and the median timing of administration was 15.6 h prior to surgery. Patient baseline, intra-operative details, rate of biliary anatomy identification, utilization ease, and surgical outcomes were assessed. Thirteen patients (11 girls), with median age at surgery of 12.9 years, underwent LC using the new RUBINA™ technology. Six patients (46.1%) had associated comorbidities and five (38.5%) were practicing drug therapy. Pre-operative workup included ultrasound (n = 13) and cholangio-MRI (n = 5), excluding biliary and/or vascular anatomical anomalies. One patient needed conversion to open surgery and was excluded from the study. The median operative time was 96.9 min (range 55–180). Technical failure of intra-operative ICG-NIRF visualization occurred in 2/12 patients (16.7%). In the other cases, ICG-NIRF allowed to identify biliary/vascular anatomic anomalies in 4/12 (33.3%), including Moynihan's hump of the right hepatic artery (n = 1), supravescicular bile duct (n = 1), and short cystic duct (n = 2). No allergic or adverse reactions to ICG, post-operative complications, or reoperations were reported. Our preliminary experience suggested that the new RUBINA™ technology was very effective to perform ICG-FC during LC in pediatric patients. The advantages of this technology include the possibility to overlay the ICG-NIRF data onto the standard white light image and provide surgeons a constant fluorescence imaging of the target anatomy to assess position of critical biliary structures or presence of anatomical anomalies and safely perform the operation. The online version contains supplementary material available at 10.1007/s00464-021-08596-7.
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DOI：
10.1089/lap.2019.0254
发表时间：
2019-06-14
影响因子：
1.3
作者：
Esposito, Ciro;Corcione, Francesco;Escolino, Maria
通讯作者：
Escolino, Maria
影响因子：
2.6
作者：
Esposito, Ciro;Alicchio, Francesca;Settimi, Alessandro
通讯作者：
Settimi, Alessandro
影响因子：
2.4
作者：
Holcomb, GW;Morgan, WM;Shyr, Y
通讯作者：
Shyr, Y
DOI：
10.1097/sle.0b013e31829cebd8
发表时间：
2014-12-01
影响因子：
1
作者：
Kala, Sanjay;Verma, Satyajeet;Dutta, Gautam
通讯作者：
Dutta, Gautam
DOI：
10.1007/s004640000042
发表时间：
2001-08-01
期刊：
SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES
影响因子：
--
作者：
Esposito, C;Sabin, MAG;Settimi, A
通讯作者：
Settimi, A