The relationship of nonsteroidal anti-inflammatory drug use to the risk of breast cancer
The relationship of nonsteroidal anti-inflammatory drug use to the risk of breast cancer
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DOI：
10.1006/pmed.1999.0518
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发表时间：
1999-08-01
影响因子：
5.1
通讯作者：
Shapiro, S
中科院分区：
文献类型：
--
作者：
Coogan, PF;Rao, RS;Shapiro, S
背景非甾体类抗炎药（NSAID）对乳腺癌风险的影响尚不清楚。我们在一项以医院为基础的病例对照研究中评估了这种关联。将这些病例（n = 6558）与癌症对照组（n = 3296）和因创伤或急性感染而入院的非癌症对照组（n = 2925）进行比较。采用多因素logistic回归模型估计比值比。对于入院前至少1年开始定期使用NSAID的女性，癌症对照组和非癌症对照组的比值比（OR）分别为0.8（95% CI 0.7，1.0）和0.7（95% CI 0.6，0.9）。在非癌症对照组中，随着使用时间的增加，比值比有统计学显著下降趋势，而在癌症对照组中则没有。定期使用的风险降低主要是由于一个研究中心（波士顿）的比值比降低，该研究中心占病例的9%。这些数据与定期使用NSAID相关的风险小幅降低是一致的。然而，数据的不一致性有损于因果解释。(C)1999年美国健康基金会和学术出版社。
Background. The effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the risk of breast cancer is unclear. We assessed the association in a hospital-based case-control study.Methods. The cases (n = 6558) were compared with cancer controls (n = 3296) and noncancer controls admitted for trauma or acute infection (n = 2925). Odds ratios were estimated using multivariate logistic regression models.Results. For women who used NSAIDs regularly beginning at least 1 year before admission, the odds ratios (OR) were 0.8 (95% CI 0.7, 1.0) with cancer controls and 0.7 (95% CI 0.6, 0.9) with noncancer controls. With noncancer controls, there was a statistically significant decreasing trend in the odds ratios as duration of use increased, whereas with cancer controls there was not. The reduction in risk for regular use was accounted for largely by a reduced odds ratio for one study center (Boston), which contributed 9% of the cases.Conclusions. The data are compatible with a small reduction in risk, associated with regular NSAID use. However, inconsistencies in the data detract from a causal interpretation. (C) 1999 American Health Foundation and Academic Press.