EVOLUTIONARILY DIFFERENT ALPHOID REPEAT DNA ON HOMOLOGOUS CHROMOSOMES IN HUMAN AND CHIMPANZEE
EVOLUTIONARILY DIFFERENT ALPHOID REPEAT DNA ON HOMOLOGOUS CHROMOSOMES IN HUMAN AND CHIMPANZEE
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DOI：
10.1073/pnas.89.8.3310
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发表时间：
1992-04-15
影响因子：
11.1
通讯作者：
BAK, AL
中科院分区：
文献类型：
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作者：
JORGENSEN, AL;LAURSEN, HB;BAK, AL
灵长类动物中的着丝粒α DNA代表了一类不断进化的重复DNA。在人类中，13号和21号染色体共享一个阿尔法DNA亚家族，而14号和22号染色体共享另一个亚家族。我们发现，类似的成对均质化发生在黑猩猩（Pan troglodytes），其中染色体14和22，同源于人类染色体13和21，共享一个部分均质化的alphoid DNA亚家族和染色体15和23，同源于人类染色体14和22，共享另一个广泛均质化的亚家族。这种同质化模式大概早于300万至1000万年前的物种形成。然而，这些人类和黑猩猩染色体上的α DNA不是直链的，而是来自两个进化上不同的重复家族。因此，在分离期间或分离后，一个或两个物种的染色体之间以协调一致的方式发生了戏剧性的序列进化。
Centromeric alphoid DNA in primates represents a class of evolving repeat DNA. In humans, chromosomes 13 and 21 share one subfamily of alphoid DNA while chromosomes 14 and 22 share another subfamily. We show that similar pairwise homogenizations occur in the chimpanzee (Pan troglodytes), where chromosomes 14 and 22, homologous to human chromosomes 13 and 21, share one partially homogenized alphoid DNA subfamily and chromosomes 15 and 23, homologous to human chromosomes 14 and 22, share another extensively homogenized subfamily. Such a pattern of homogenization presumably predates speciation 3-10 million years ago. However, the alphoid DNA on these human and chimpanzee chromosomes is not orthologous but originates from two evolutionarily different repeat families. It follows that dramatic sequence evolution has occurred in a concerted fashion among the chromosomes in one or both species during or after separation.