General Anesthetic Action on γ‐Aminobutyric Acid—Activated Channels
General Anesthetic Action on γ‐Aminobutyric Acid—Activated Channels
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对 γ-氨基丁酸激活通道的全身麻醉作用
DOI：
10.1111/j.1749-6632.1991.tb33839.x
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发表时间：
1991
影响因子：
5.2
通讯作者：
E. Brunner
中科院分区：
文献类型：
--
作者：
J. Yeh;F. N. Quandt;J. Tanguy;M. Nakahiro;T. Narahashi;E. Brunner
突触传递比神经传导更容易受到各种麻醉剂的阻断作用的影响。有两种方式可以破坏突触传递：一是抑制兴奋性反应;二是加强抑制性反应。早期的工作表明，包括挥发性麻醉剂和巴比妥类药物在内的各种全身麻醉剂在麻醉剂浓度与全身麻醉所需浓度相当的情况下确实可以抑制许多制剂中的兴奋性突触传递。随后的工作表明，许多全身麻醉药可以增强抑制反应而不影响兴奋反应。几个观察结果进一步支持这样的观点，即中枢神经系统中由γ-氨基丁酸（GABA）介导的抑制性突触是各种麻醉剂的潜在作用部位。z6首先，当给予大鼠和小鼠时，GABA类似物THIP能够诱导麻醉。第二，巴比妥类药物、甾体麻醉剂和苯二氮卓类药物在临床相关浓度下可增强培养神经元中GABA激活的反应，并增强从大脑不同区域记录到的抑制性突触后电流（IPSC）或电位（IPSP）。巴比妥类药物和苯二氮卓类药物影响GABA受体的机制已通过电生理技术详细研究。GABA激活电流的波动分析表明，这两种类型的药物通过不同的机制增强GABA反应，这已经通过使用培养神经元中GABA激活通道的单通道记录详细解决。'^
Synaptic transmission is more susceptible than nerve conduction to the blocking action of a variety of anesthetic agents.'There are two ways by which synaptic transmission can be disrupted: one, to suppress the excitatory response; two, to potentiate the inhibitory response. The early work showed that a variety of general anesthetics including volatile anesthetics and barbiturates can indeed suppress excitatory synaptic transmission in many preparations at concentrations of anesthetic comparable to those required for general anesthesia. Subsequent work showed that many general anesthetics can potentiate the inhibitory response without affecting the excitatory re~ ponse.~-~ Several observations further support the view that the inhibitory synapse, mediated by y-aminobutyric acid (GABA), in the central nervous system is a potential site of action of various anesthetics.] z6 First, the GABA analogue THIP is capable of inducing anesthesia when administrated to rats and mice.'Second, barbiturates, steroidal anesthetics, and benzodiazepine potentiate the GABA-activated response in cultured neuronsRy and inhibitory postsynaptic currents (IPSCs) or potentials (IPSPs) recorded from various regions of brain at clinically relevant concentrati~ ns.~~~~'~~'~The mechanisms by which barbiturates and benzodiazepines affect the GABA receptor have been studied in detail by electrophysiological techniques. Fluctuation analysis of GABA-activated currents indicates that these two types of drugs potentiate the GABA response through different mechanisms," which have been resolved in detail by using single channel recordings of the GABA-activated channel in cultured neuron^.'^
DOI：
10.1085/jgp.84.4.535
发表时间：
1984
期刊：
The Journal of general physiology
影响因子：
--
作者：
Vandenberg,CA;Horn,R
通讯作者：
Horn,R
全细胞记录过程中γ-氨基丁酸A受体功能的“衰退”：磷酸化的可能作用。
影响因子：
3.6
作者：
Gyenes,M;Farrant,M;Farb,DH
通讯作者：
Farb,DH
麻醉药物对γ-氨基丁酸受体-氯离子通道复合物的神经化学作用。
DOI：
--
发表时间：
1987
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Huidobro-Toro,JP;Bleck,V;Allan,AM;Harris,RA
通讯作者：
Harris,RA