Tracking Longitudinal Retinal Changes in Experimental Ocular Hypertension Using the cSLO and Spectral Domain-OCT
Tracking Longitudinal Retinal Changes in Experimental Ocular Hypertension Using the cSLO and Spectral Domain-OCT
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DOI：
10.1167/iovs.10-5551
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发表时间：
2010-12-01
影响因子：
4.4
通讯作者：
Cordeiro, M. Francesca
中科院分区：
文献类型：
--
作者：
Guo, Li;Normando, Eduardo M.;Cordeiro, M. Francesca
目的。在青光眼中，外视网膜的受累是有争议的。本研究的目的是测试，首先，在实验性高眼压(OHT)中，视网膜外部是否受到影响，其次，整个视网膜厚度是否可以作为青光眼改变的替代标志。使用改良的SpectralisOCT(海德堡工程，海德堡，德国)在基线、OHT诱导后3周和8周对动物进行成像。结果：正常眼视网膜总厚度为172.19+/-5.17µm，无明显地区差异。在第3周和第8周，OHT导致整个视网膜厚度和外核层(ONL)显著减少(P<；0.05)，以及预期的视网膜神经纤维层(RNFL)变薄。全视网膜厚度与RNFL(P=0.035)和ONL(P
PURPOSE. Involvement of the outer retina is controversial in glaucoma. The aim of this study was to test, first, whether the outer retina is affected in experimental ocular hypertension (OHT) and, second, whether whole retinal thickness can be used as a surrogate marker of glaucomatous change.METHODS. OHT was surgically induced in 20 Dark Agouti rats. Animals were imaged using a modified Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) at baseline and at 3 and 8 weeks after OHT induction. Measurements were recorded for whole and individual retinal layer thickness in four regions-temporal, superior, nasal, and inferior-around the optic nerve head.RESULTS. Whole retinal thickness in normal eyes was 172.19 +/- 5.17 mu m, with no significant regional differences. OHT caused a significant reduction in whole retinal thickness and the outer nuclear layer (ONL) at 3 and 8 weeks (P < 0.05), along with the expected thinning of the retinal nerve fiber layer (RNFL). Whole retinal thickness correlated well with RNFL (P = 0.035) and ONL (P