Modelling the impact of HPV vaccines on cervical cancer and screening programmes
Modelling the impact of HPV vaccines on cervical cancer and screening programmes
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DOI：
10.1016/j.vaccine.2006.05.116
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发表时间：
2006-08-31
期刊：
影响因子：
5.5
通讯作者：
Goldie, Sue J.
中科院分区：
文献类型：
--
作者：
Garnett, Geoffrey P.;Kim, Jane J.;Goldie, Sue J.
人类乳头瘤病毒(HPV)-16/18疫苗接种对感染和疾病发生率的影响可以在一系列不同的模型中进行探索。在这里，我们探索疫苗接种的流行病学和经济影响，在没有筛查的情况下，在疫苗接种已经确立的情况下。强调了关于自然获得免疫和风险行为异质性的假设对流行病学的重要性，以及疫苗成本和修改筛查策略的能力对卫生经济结果的重要性。到目前为止，模型结果在预测疫苗的有用作用方面是一致的，但需要进一步的流行病学数据来帮助测试模型的有效性。(C)2006爱思唯尔有限公司。保留所有权利。
The impact of human papillomavirus (HPV)-16/18 vaccination on the incidence of infection and disease can be explored in a range of different models. Here we explore the epidemiological and economic impact of vaccination where screening is absent and where it is well established. The importance for epidemiology of assumptions about naturally-acquired immunity and heterogeneity in risk behaviours are highlighted, as are the importance for health economic outcomes of vaccine costs and the ability to modify screening strategies. To date, model results are consistent in predicting a useful role for vaccine, but further epidemiological data are required to help test the validity of models. (c) 2006 Elsevier Ltd. All rights reserved.