Molecular imaging in atherosclerosis, thrombosis, and vascular inflammation.
Molecular imaging in atherosclerosis, thrombosis, and vascular inflammation.
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动脉粥样硬化、血栓形成和血管炎症的分子成像。
DOI：
10.1161/atvbaha.108.165498
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发表时间：
2009-07
影响因子：
8.7
通讯作者：
Fisher, Edward A.
中科院分区：
文献类型：
--
作者：
Choudhury, Robin P.;Fisher, Edward A.
对动脉粥样硬化、血栓形成和血管炎症的分子和细胞过程的认识已经确定了成像的新靶点。分子成像方法的共同目标是加速和完善诊断，提供揭示疾病多样性的见解，指导特定治疗并监测这些治疗的效果。在这里，我们进行了比较分析的成像方式，已被用于这一疾病领域。我们认为造影剂的元素，强调如何了解动脉粥样硬化及其并发症的生物学可以通知最佳设计。我们解决的潜力和局限性，目前的对比方法在翻译为临床可用的代理商和推测未来的应用。
Appreciation of the molecular and cellular processes of atherosclerosis, thrombosis and vascular inflammation has identified new targets for imaging. The common goals of molecular imaging approaches are to accelerate and refine diagnosis, provide insights that reveal disease diversity, guide specific therapies and monitor the effects of those therapies. Here we undertake a comparative analysis of imaging modalities that have been used in this disease area. We consider the elements of contrast agents, emphasizing how an understanding of the biology of atherosclerosis and its complications can inform optimal design. We address the potential and limitations of current contrast approaches in respect of translation to clinically usable agents and speculate on future applications.