Inhibition of T‐Cell Activity by Cyclosporin A
Inhibition of T‐Cell Activity by Cyclosporin A
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环孢素 A 抑制 T 细胞活性
DOI：
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发表时间：
1982
影响因子：
3.7
通讯作者：
K. Lafferty
中科院分区：
文献类型：
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作者：
L. Andrus;K. Lafferty
环孢菌素A（CyA）抑制T细胞反应中的早期事件。它强烈抑制IL 1或IL 2和同种异体抗原对初始T细胞的活化。CyA对活化的T细胞发挥选择性作用，它抑制这些细胞响应抗原或有丝分裂原再刺激而释放IL 2的能力，其浓度对这些相同细胞群通过增殖响应IL 2的能力没有影响。然而，CyA的特异性作用并不限于T细胞，该药物将抑制脂多糖W刺激的PU 5-IR细胞产生IL 1。
Cyclosporin A (CyA) inhibits early events in the T‐ccll response. It strongly suppresses the activation of naive T cells by IL1 or IL2 and alloantigen. CyA exerts a selective effect on activ ated T cells, It inhibits the ability of these cells to release IL2 in response to antigen or mitogen restimulation, at concentrations that have no effect on the ability of these same cell populations to respond to IL2 by proliferation. The specific effects of CyA are not limited to T cells, however, and this drug will inhibit IL1 production by lipopolysaccharide W‐stimulated PU5‐IR cells.