Mechanisms of action of zinc in acute diarrhea
Mechanisms of action of zinc in acute diarrhea
复制标题
DOI：
10.1097/mog.0b013e32833fd48a
复制
发表时间：
2011-01-01
影响因子：
2.5
通讯作者：
Passariello, Annalisa
中科院分区：
文献类型：
--
作者：
Canani, Roberto Berni;Buccigrossi, Vittoria;Passariello, Annalisa
综述的目的十多年来，锌在治疗急性腹泻中的重要性已被认识到。最近，锌的作用机制变得越来越清楚。本文综述了锌在急性腹泻中作用机制的新证据。最近的发现绝大多数数据来自使用肠细胞系的体外研究或来自动物模型。锌在急性腹泻中的积极作用来自于对肠液转运、粘膜完整性、免疫、基因表达和氧化应激的调节。一个复杂的稳态网络也能够调节锌状态在细胞和细胞外level.SummaryAll这些数据支持使用锌在治疗急性腹泻，但需要进一步的临床研究，以探讨锌对特定病原体腹泻负责的选择性影响。
Purpose of reviewFor over a decade, the importance of zinc in the treatment of acute diarrhea has been recognized. More recently, the mechanisms of action of zinc are becoming clearer. This review is focused on the new evidence on the mechanisms of action of zinc in acute diarrhea.Recent findingsThe vast majority of data derive from in-vitro studies using intestinal cell lines or from animal model. The positive action by zinc in acute diarrhea derives from a regulation of intestinal fluid transport, mucosal integrity, immunity, gene expression, and oxidative stress. A complex homeostatic network is also able to regulate zinc status at cellular and extracellular level.SummaryAll these data support the use of zinc in the treatment of acute diarrhea, but further clinical studies are needed to explore the selective effects of zinc against specific pathogens responsible for diarrhea.