Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
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DOI：
10.1016/j.bmcl.2010.05.079
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发表时间：
2010-07-15
影响因子：
2.7
通讯作者：
Lee, Kuo-Hsiung
中科院分区：
文献类型：
--
作者：
Dong, Yizhou;Nakagawa-Goto, Kyoko;Lai, Chin-Yu;Morris-Natschke, Susan L.;Bastow, Kenneth F.;Lee, Kuo-Hsiung
关键词：
4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs were designed, synthesized, and evaluated for cytotoxic activity. Among all 4-substituted ABO analogs, cyclohexyl (12), N-methoxy-N-methylacetamide (14), and various aromatic derivatives (15-25 and 27) exhibited promising cell growth inhibitory activity with ED50 values of 0.01-2.1 μM against all tested tumor cell lines. The 4′-methoxyphenyl derivative (18) and 3′-methylphenyl derivative (24) showed the most potent antitumor activity against a broad range of cancer cell lines with ED50 values of 0.01-0.17 μM. Preliminary SAR results indicated that substitutions on nitrogen are critical to the antitumor potency.
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影响因子：
7.3
作者：
Dong Y;Shi Q;Liu YN;Wang X;Bastow KF;Lee KH
通讯作者：
Lee KH
影响因子：
7.3
作者：
Dong Y;Shi Q;Pai HC;Peng CY;Pan SL;Teng CM;Nakagawa-Goto K;Yu D;Liu YN;Wu PC;Bastow KF;Morris-Natschke SL;Brossi A;Lang JY;Hsu JL;Hung MC;Lee EY;Lee KH
通讯作者：
Lee KH
影响因子：
2.1
作者：
Alberola, A;Alvaro, R;Sañudo, MC
通讯作者：
Sañudo, MC
DOI：
10.1016/s0014-827x(03)00160-5
发表时间：
2003-11-01
期刊：
Farmaco (Lausanne)
影响因子：
--
作者：
Di Braccio, Mario;Grossi, Giancarlo;Bordin, Franco
通讯作者：
Bordin, Franco
影响因子：
2.8
作者：
Rishton, Gilbert M.
通讯作者：
Rishton, Gilbert M.