S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mitochondrial function
S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mitochondrial function
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DOI：
10.1016/j.ejphar.2008.12.027
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发表时间：
2009-02-14
影响因子：
5
通讯作者：
Sironi, Luigi
中科院分区：
文献类型：
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作者：
Gelosa, Paolo;Banfi, Cristina;Sironi, Luigi
S 35171是被设计用于保护线粒体功能的化合物家族之一。我们检验了S 35171在自发性高血压卒中易感大鼠（SHRSPs）中发挥保护作用的假设，SHRSPs是一种发生自发性脑损伤的动物模型，在此之前发生蛋白尿和全身性炎症，表现为源自肝脏的急性时相蛋白（APP）的尿液蓄积。喂食允许饲料的雄性SHRSP在高钠饲料（A组）或蛋白尿建立后（B组）开始接受溶媒或S 35171（10 mg/kg/天）。药物延迟了尿APPs的积累和磁共振成像（MRI）监测的脑损伤的出现（A组62 3天，对照组51 2天，P
S 35171 is one of a family of compounds that have been designed to protect mitochondrial function. We tested the hypothesis that S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats (SHRSPs), an animal model developing spontaneous brain damage preceded by proteinuria and systemic inflammation revealed by the urinary accumulation of acute-phase proteins (APPs) originating in the liver. Male SHRSPs fed a permissive diet received vehicle or S 35171 (10 mg/kg/day) started simultaneously with a high-sodium diet (group A) or after the establishment of proteinuria (group B). The drug delayed urinary APPs accumulation and the appearance of magnetic resonance imaging (MRI)-monitored brain lesions (after 62 3 days in group A, and 51 2 days in controls, P