Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres
Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres
复制标题
DOI：
10.1002/adfm.202106572
复制
发表时间：
2021-11
影响因子：
19
通讯作者：
Xinyu Sun;Pei Jia;Hui Zhang;Mengna Dong;Jiao Wang;Lihua Li;Tong Bu;Xin Wang;Li Wang;Q. Lu;Jihao Wang
中科院分区：
文献类型：
--
作者：
Xinyu Sun;Pei Jia;Hui Zhang;Mengna Dong;Jiao Wang;Lihua Li;Tong Bu;Xin Wang;Li Wang;Q. Lu;Jihao Wang
再生创面敷料的目标是将组织功能恢复到正常的生理活动，并加速伤口部位的皮肤组织再生。实现这一目的的最佳策略需要在材料功能、降解、安全性和组织再生之间取得平衡。本文首次提出了一种超声触发趋向平衡自组装的不可逆离子交联共驱动策略来制备多功能肉桂醛-单宁酸-醋酸锌纳米球(CA-TA-Za NSS)，实现了亲水性和疏水性药物-食品小分子的融合。此外，通过将药物-食品小分子自组装的CA-TA-Za NSS引入CS的三维网络结构，设计了一种新型的集抗菌、抗氧化、抗炎和减轻氧化应激损伤能力于一体的“一体式”壳聚糖(CS)水凝胶。此外，多功能CS水凝胶可在创面实现快速原位凝胶化，并完全覆盖不规则创面。所有这些优势使CS水凝胶能够清洁伤口微环境，诱导皮肤组织重塑，促进血管修复和毛囊再生，恢复免疫系统的正常生理活动，促进伤口愈合。因此，本研究为生物医学领域具有巨大应用潜力的先进功能材料的设计提供了新的视角。
The goal of regenerative wound healing dressings is to restore tissue function back to normal physiological activity and accelerate skin tissue regeneration at wound sites. The optimal strategy to achieve this purpose requires a balance between material functionality, degradation, safety, and tissue regrowth. Herein, for the first time, an ultrasonic‐triggered irreversible tending to equilibrium self‐assembly and ionic cross‐linking codriven strategy is proposed for producing multifunctional cinnamaldehyde‐tannic acid‐zinc acetate nanospheres (CA‐TA‐ZA NSs), realizing the fusion of hydrophilic and hydrophobic drug‐food small molecules. Moreover, a novel “all‐in‐one” chitosan (CS)‐based hydrogel functionalized by introducing drug‐food small molecules self‐assembled CA‐TA‐ZA NSs to the 3D network structures of CS is designed, integrating excellent antibacterial, antioxidant, anti‐inflammatory and reducing oxidative stress damage abilities. Additionally, the multifunctional CS‐based hydrogel can realize rapid in situ gelation at wound sites and completely cover the irregular wounds. All of these superiorities enable the CS‐based hydrogel to clean the wound microenvironment, induce skin tissue remodeling, promote blood vessel repair and hair follicle regeneration, restore the immune system back to normal physiological activity, and accelerate wound healing. Therefore, this study offers a new perspective for the design of advanced functional materials with great application potential in the biomedical field.