Effects of cardiac pulsation in diffusion tensor imaging of the rat brain.
Effects of cardiac pulsation in diffusion tensor imaging of the rat brain.
复制标题
心脏搏动对大鼠脑扩散张量成像的影响。
DOI：
10.1016/j.jneumeth.2010.10.003
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发表时间：
2010
影响因子：
3
通讯作者：
Poptani,Harish
中科院分区：
文献类型：
--
作者：
Kim,Sungheon;Pickup,Stephen;Poptani,Harish
本研究旨在探讨心脏搏动对大鼠脑扩散张量成像(DTI)的影响。DTI数据是在有或没有不同的心脏门控延迟的情况下获得的。对于每种情况，获取两组相同的DTI数据用于Bootstrap分析，以测量估计平均扩散率(MD)、分数各向异性(FA)和主特征向量方向的不确定度。与不使用门控或使用触发延迟为0ms的门控时相比，使用触发延迟为70ms(R-R峰值持续时间的∼的一半)的心脏门控时，主特征向量的95%可信区间显著减小(21-25%)。MD和FA估计的标准偏差也分别减少了12-26%和13-24%。对于平均FA值大于0.15而小于0.95的体素，触发延迟为70ms时，心脏门控的CI和MD和FA的标准差显著降低(p<；0.05)。这些结果证明了心脏门控在获取体内高分辨率DTI数据方面的重要性。
The purpose of this study was to investigate the effects of cardiac pulsation in diffusion tensor imaging (DTI) of the rat brain. DTI data were acquired either with or without different cardiac gating delays. For each case, two sets of identical DTI data were acquired for a bootstrap analysis to measure the uncertainty in estimating mean diffusivity (MD), fractional anisotropy (FA) and the primary eigenvector direction. The 95% confidence interval of the primary eigenvectors was substantially reduced (21–25%) when cardiac gating with triggering delay of 70ms (∼half of R–R peak duration) was used in comparison to studies without gating or when gating with a triggering delay of 0ms was used. Standard deviations of MD and FA estimates were also reduced by 12–26% and 13–24%, respectively. For voxels with mean FA values larger than 0.15 and smaller than 0.95, the decrease in CI and standard deviations of MD and FA by cardiac gating with triggering delay of 70ms were significant (p<0.05). These results demonstrate the importance of cardiac gating in acquisition of in vivo high resolution DTI data.