Control of T helper cell differentiation--in search of master genes.
Control of T helper cell differentiation--in search of master genes.
复制标题
DOI：
10.1126/stke.2000.49.pe1
复制
发表时间：
2000-09-12
期刊：
影响因子：
--
通讯作者：
Flavell, R A
中科院分区：
文献类型：
--
作者：
Dong, C;Flavell, R A
幼稚 T 辅助细胞 (T(H)0) 可以分化为两个不同群体之一：T(H)1 和 T(H)2。每个群体的特征在于特定细胞因子的表达及其参与细胞介导或体液免疫反应的能力。最近在确定 T(H)0 细胞变成 T(H)1 或 T(H)2 细胞的分子机制方面的努力一直很有希望。已鉴定出许多转录因子，包括 GATA-3 和 T-bet，可促进 T(H)0 细胞的分化和分化细胞表型的维持。 Dong 和 Flavell 回顾了控制 T(H)0 分化命运的蛋白质的最新发现，无论是通过促进还是抑制，并讨论了表观发生在分化过程中的作用。
Naive T helper (T(H)0) cells can differentiate into one of two distinct populations: T(H)1 and T(H)2. Each population is characterized by the expression of specific cytokines and their ability to participate in cell-mediated or humoral immune responses. Recent efforts at identifying the molecular mechanisms through which T(H)0 cells become T(H)1 or T(H)2 cells have been promising. A number of transcription factors, including GATA-3 and T-bet, have been identified that promote the differentiation of T(H)0 cells and the maintenance of the differentiated cell phenotype. Dong and Flavell review recent findings on proteins that control the fate of T(H)0 differentiation, whether by promotion or inhibition, and discuss the role of epigenesis in the differentiation process.