Antibody Response in Korean Raccoon Dogs Inoculated with Inactivated Rabies Vaccines
Antibody Response in Korean Raccoon Dogs Inoculated with Inactivated Rabies Vaccines
复制标题
接种灭活狂犬病疫苗的韩国貉的抗体反应
DOI：
--
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Jae
中科院分区：
文献类型：
--
作者：
Dong;Taesik Go;Young Hee Nam;Ha Hyun Kim;Soo;Kyung;Sung;Jae
自1993年在韩国首次发现森林狂犬病以来，已向狂犬病危险地区分发了300多万剂诱饵疫苗，以阻止狂犬病在野生动物之间的传播。为了在狂犬病危险地区完全消除森林狂犬病，需要新的渐进战略。在实施根除相关预防计划之前，必须对韩国现有的狂犬病灭活疫苗进行免疫原性评价。对京畿道野生动物救助中心的6组貉进行了6剂市售狂犬病灭活疫苗（A ~ F）的肌肉注射。采用病毒中和试验（VNA）对接种时、接种后2周和4周的血清样本进行分析。所有接种C、D、E或F疫苗的貉均显示VN抗体滴度在0.5 ~ 13.77 IU/ml之间。接种B疫苗的4只貉中有一半的VN滴度超过0.5 IU/ml，接种A疫苗的4只貉中有1只显示保护性抗体滴度。本研究结果提示，市售的大部分狂犬病灭活疫苗均能诱导韩国貉产生保护性免疫，适用于新的狂犬病控制方案。
Since sylvatic rabies was first identified in South Korea in 1993, over three million bait vaccine doses have been distributed to rabies risk regions in order to block transmission of rabies among wild animals. New progressive strategy is needed to eliminate sylvatic rabies completely in rabies risk regions. Before applying the preventive program related to eradication, immunogenicity of inactivated rabies vaccines available in Korea has to be evaluated in Korean raccoon dogs (Nyctereutes procyonoides koreensis). Six groups of raccoon dogs in wild rescue center of Gyeonggi-do were vaccinated intramuscularly with single dose of six inactivated commercial rabies vaccines (designated A to F). Serum samples at the time of vaccination, and two and four weeks post vaccination were obtained and analyzed by virus neutralizing assay (VNA). All raccoon dogs inoculated with vaccines C, D, E or F, showed VN antibody titers ranging from 0.5 to 13.77 IU/ml. Half of four raccoon dogs immunized with vaccine B revealed VN titer over 0.5 IU/ml, and one of four raccoon dogs inoculated with vaccine A showed protective antibody titer. This finding suggests that most of the commercially available inactivated rabies vaccines could induce protective immunity in Korean raccoon dogs and be applicable to new rabies control program.