Self-Reporting Colorimetric Analysis of Drug Release by Molecular Imprinted Structural Color Contact Lens
Self-Reporting Colorimetric Analysis of Drug Release by Molecular Imprinted Structural Color Contact Lens
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DOI：
10.1021/acsami.8b11655
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发表时间：
2018-10-10
影响因子：
9.5
通讯作者：
Xie, Zhuoying
中科院分区：
文献类型：
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作者：
Deng, Jingzhe;Chen, Shan;Xie, Zhuoying
隐形眼镜作为一种极具发展前景的眼科给药设备，因其药物停留时间和生物利用度的提高而备受关注。本研究提出并制备了一种分子印迹结构色隐形眼镜，可通过颜色变化自我报告噻洛尔的释放过程。分子印迹位点对目标噻洛尔的特异性识别不仅可以增加药物的载药量和停留时间，而且随着噻洛尔的累积释放，使晶体的结构颜色发生显著的蓝移。该迷人的隐形眼镜可进一步用于控制大量眼科药物的释放，具有很高的潜力成为新一代功能性隐形眼镜。
As a prospective ophthalmic drug delivery device, contact lenses attract a lot of attention because of the improved drug residence time and bioavailability. Herein, we proposed and fabricated a molecular imprinted structural color contact lens for sustained timolol release which could self report the release process by color change. The specific recognition of target timolol by molecular imprinted sites can not only increase the loading amount and the residence time of the drug but also endow the structure color of lens remarkable blue shift with the accumulative release of timolol. The fascinating contact lens can be further used for controlling release of a large number of ophthalmic drugs and has high potential to be a new generation of functional contact lenses.