NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates
NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates
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DOI：
10.1111/j.1469-0691.2011.03726.x
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发表时间：
2012-02-01
影响因子：
14.2
通讯作者：
Pal, T.
中科院分区：
文献类型：
--
作者：
Ghazawi, A.;Sonnevend, A.;Pal, T.
对阿布扎比医院回收的155株碳青霉烯类非敏感鲍曼不动杆菌菌株进行筛选，发现了2株携带金属β-内酰胺酶blaNDM基因的菌株。它们与一名曾在埃及、黎巴嫩和阿拉伯联合酋长国接受过治疗的癌症患者的尿液分离了4个月。它们是克隆相关的，携带最近在埃及和以色列的鲍曼不动杆菌中发现的blaNDM-2基因。blaNDM-2基因周围的序列与肠杆菌科和鲍曼不动杆菌中的blaNDM-1相关序列具有显著的相似性。在中东地区反复分离出类似鲍曼不动杆菌的blaNDM-2阳性不动杆菌，这增加了当地出现和传播独特克隆的可能性。
Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-beta-lactamase blaNDM gene-carrying isolates. They were isolated 4 months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the blaNDM-2 gene recently identified in A.similar to baumannii in Egypt and Israel. Sequences surrounding the blaNDM-2 gene showed significant similarities with those associated with blaNDM-1 in Enterobacteriaceae and A.similar to baumannii. Repeated isolation of blaNDM-2-positive A.similar to baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.