Cocaine-induced neuroadaptations in glutamate transmission Potential therapeutic targets for craving and addiction
Cocaine-induced neuroadaptations in glutamate transmission Potential therapeutic targets for craving and addiction
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DOI：
10.1111/j.1749-6632.2009.05144.x
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Pierce, R. Christopher
中科院分区：
文献类型：
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作者：
Schmidt, Heath D.;Pierce, R. Christopher
越来越多的证据表明，重复接触可卡因会导致边缘核，特别是丘脑核中谷氨酸传输的深刻变化。本文综述了可卡因诱导的行为可塑性的临床前研究，包括行为敏化，自我管理，可卡因寻求的恢复。行为，药理学，神经化学，电生理学，生物化学和分子生物学的变化与可卡因诱导的谷氨酸系统的可塑性进行了审查。这些研究的最终目标是确定开发可卡因渴望和成瘾疗法的新目标。因此，我们也概述了谷氨酸调节剂用于治疗可卡因成瘾的进展和前景。
A growing body of evidence indicates that repeated exposure to cocaine leads to profound changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This review focuses on preclinical studies of cocaine-induced behavioral plasticity, including behavioral sensitization, self-administration, and the reinstatement of cocaine seeking. Behavioral, pharmacological, neurochemical, electrophysiological, biochemical, and molecular biological changes associated with cocaine-induced plasticity in glutamate systems are reviewed. The ultimate goal of these lines of research is to identify novel targets for the development of therapies for cocaine craving and addiction. Therefore, we also outline the progress and prospects of glutamate modulators for the treatment of cocaine addiction.