DEVELOPMENT OF SENSORY INNERVATION IN DENTIN
DEVELOPMENT OF SENSORY INNERVATION IN DENTIN
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DOI：
10.1002/cne.901910307
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
BYERS, MR
中科院分区：
文献类型：
--
作者：
BYERS, MR
用放射性蛋白轴突运输法标记3周龄~ 1岁大鼠牙本质神经，用放射自显影法检测牙本质发育中的神经。除了神经生长，2个过程决定成人牙本质神经的位置：在牙本质形成的最后几周期间，神经在牙髓周围牙本质小管内的封闭，从牙髓角的尖端开始并扩展到包括大多数冠状牙本质，并且由于牙本质磨损和被非神经支配的替代，牙尖尖端附近的神经逐渐丧失，磨牙萌出前数天，牙尖神经已开始被牙本质包裹; 2-3周后，当牙尖牙本质形成减慢时，哪个区域的神经支配大部分建立，神经延伸到牙本质中达160 μ m，并且磨牙已经达到功能性咬合的阶段。初始咬合后不久，牙本质磨损和替换的非神经支配的修复性牙本质的过程开始，然而，同时牙本质发生在更多的顶端区域产生新的神经支配的牙本质。神经位置与牙本质生长线的关系进行了研究。神经末梢与牙本质小管中特定位点的长期关联被发现。大鼠磨牙和人类恒牙牙的牙本质神经支配的发展之间的相似性进行了讨论;发现随着牙齿的成熟，对疼痛刺激变得更加敏感，牙本质神经的密度增加。
Dental nerves of 3-wk- to 1-yr-old rats were labeled by axonal transport of radioactive protein to detect nerves in developing dentin by autoradiography. In addition to nerve growth, 2 processes determine adult dentinal nerve location: enclosure of nerves within circumpulpal dentinal tubules during the last few weeks of dentinogenesis, beginning at the tip of the pulp horn and spreading to include most coronal dentin and gradual loss of the nerves near the tip of the cusp because of dentinal attrition and replacement by noninnervated, reparative dentin were found. Several days before a molar erupts, nerves at the tip of the cusp have already begun to be enclosed by dentin; 2-3 wk later, when dentinogenesis at the cusp tip slows down, most of the innervation for what region was established, nerves extend up to 160 .mu.m into dentin and the molar has reached the stage of functional occlusion. Soon after initial occlusion, the process of dentinal attrition and replacement by noninnervated reparative dentin begins; however, simultaneous dentinogenesis in more apical regions produces new innervated dentin. Nerve position in relation to dentin growth lines was studied. A long-term association of nerve endings with specific sites in the dentinal tubules was found. The similarities between the development of dentinal innervation in rat molars and in human permanent teeth are discussed; it is found that as teeth mature and become more sensitive to painful stimuli, the density of dentinal nerves increases.