A feasible method for clinical delivery verification and dose reconstruction in tomotherapy
A feasible method for clinical delivery verification and dose reconstruction in tomotherapy
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DOI：
10.1118/1.1352579
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发表时间：
2001-04-01
期刊：
影响因子：
3.8
通讯作者：
Mackie, TR
中科院分区：
文献类型：
--
作者：
Kapatoes, JM;Olivera, GH;Mackie, TR
输送验证是对治疗期间输送的能量通量进行验证的过程。该经验证的能量通量可以与治疗位置中的图像结合使用，以重建沉积的全三维剂量。在这项工作中描述了一种利用检测器信号的测量数据库进行交付验证的方法。该数据库是两个参数的函数，即放射路径长度和探测器到体模距离，这两个参数都是根据输送时拍摄的CT图像计算的。生成这样的数据库并用于执行输送验证和剂量重建。进行了两个实验：一个模拟的前列腺交付的不均匀的腹部模型，和鼻咽交付的狗尸体。对于这两种情况，发现使用数据库方法验证的通量和剂量结果与使用先前开发和验证的技术的结果非常一致。在治疗时使用测量数据库和CT图像进行输送验证是断层治疗的准确程序。该数据库消除了对任何患者特定的治疗前或治疗后测量的需要。此外，这样的方法在给定快速图像重建和剂量计算工具的情况下为准确、实时的递送验证和剂量重建创造了机会。(C)2001年美国医学物理学家协会。
Delivery verification is the process in which the energy fluence delivered during a treatment is verified. This verified energy fluence can be used in conjunction with an image in the treatment position to reconstruct the full three-dimensional dose deposited. A method for delivery verification that utilizes a measured database of detector signal is described in this work. This database is a function of two parameters, radiological path-length and detector-to-phantom distance, both of which are computed from a CT image taken at the time of delivery. Such a database was generated and used to perform delivery verification and dose reconstruction. Two experiments were conducted: a simulated prostate delivery on an inhomogeneous abdominal phantom, and a nasopharyngeal delivery on a dog cadaver. For both cases, it was found that the verified fluence and dose results using the database approach agreed very well with those using previously developed and proven techniques. Delivery verification with a measured database and CT image at the time of treatment is an accurate procedure for tomotherapy. The database eliminates the need for any patient-specific, pre- or post-treatment measurements. Moreover, such an approach creates an opportunity for accurate, real-time delivery verification and dose reconstruction given fast image reconstruction and dose computation tools. (C) 2001 American Association of Physicists in Medicine.